PDIA3 Antibodies

Protein disulfide-isomerase A3 (PDIA3)

Gene Information

Human
Gene Name:	PDIA3
Uniprot:	P30101
Entrez:	2923

Family

Belongs to:
protein disulfide isomerase family

Alternative Names

Disulfide isomerase ER-60; EC 5.3.4.1; endoplasmic reticulum P58; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; ER protein 60; ER60; ERp57; ERp5758 kDa glucose-regulated protein; ERp60; ERp6058 kDa microsomal protein; ERp61; glucose regulated protein, 58kDa; GRP57; GRP58; GRP58ER protein 57; HsT17083; P58; PDIA3; phospholipase C-alpha; PI-PLC; protein disulfide isomerase family A, member 3; protein disulfide isomerase-associated 3; protein disulfide-isomerase A3

Molecular Weight

Mass (kDA):
56.782 kDA

Genomic Context

Human
Location:	15q15.3
Sequence:	15; NC_000015.10 (43746438..43773278)

Tissue Specificity

Detected in the flagellum and head region of spermatozoa (at protein level).

Subcellular Localizations

Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Physiological Stress
• Inflammation
• Endoplasmic Reticulum Stress
• Melanoma
• Liver Carcinoma
• Ovarian Neoplasm
• Neoplasm Metastasis
• Malignant Neoplasm Of Ovary
• Cell Invasion
• Virus Diseases

• Neuroblastoma
• Tissue Adhesions
• Malignant Neoplasm Of Breast
• Autoimmune Diseases
• Cell Transformation, Neoplastic
• Autoimmune Reaction
• Malignant Paraganglionic Neoplasm

Interacting Proteins

• APP
• Calr
• CLU
• ERO1A
• ERO1B

• PRDX4
• STIM1
• TAP1

Pathways

• Protein Folding
• Localization
• Transport
• Secretion
• Glycosylation
• Pathogenesis
• Secretory Pathway
• Cell Death
• Dna Repair
• Translation
• Flight
• Cell Cycle
• Rna Interference

• Antigen Processing And Presentation
• Fertilization
• Immune Response
• Cell Adhesion
• Spermatogenesis
• Cell Proliferation
• Glycolysis

PTMs

• Glycosylation
• Phosphorylation
• Oxidation
• Reduction
• Cleavage

• Biotinylation
• Phosphorothioation
• Farnesylation
• Amidation
• Methylation

Research Areas

• Cellular Markers
• ER Markers
• Membrane Trafficking and Chaperones

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDIA3

Best Uses Of The PDIA3 Marker

This article will explore the various research applications of the ERp57/PDIA3 marker. It is not yet approved for clinical trials or diagnostics for humans, despite being a valuable research instrument. It is still an important research tool that should be widely utilized. Read on to learn more. Below are the top uses of the PDIA3 marker. Below are some examples of possible uses.

The ERp57/PDIA3 target is a significant research target

ERp57/PDIA3 is a protein expressed in the respiratory epithelial cells of mice. It is involved in the formation of disulfide bonds that are essential for creating inflammation, infection or hyperresponsiveness to airways. The ERp57/PDIA3 protein also has a variety of other roles and functions. In the present study, we focused on the function of this protein in signaling pathways that are initiated by membranes and carcinogenesis.

ERp57/PDIA3 has been previously associated with cell membrane as well as extracellular localization. It was previously misinterpreted by phospholipase C beta, and was believed to interact with angiotensin II. However, recent research has demonstrated that ERp57/PDIA3 resides on the cell's surface conjunction with calreticulin. It also is involved in the death of immuneogenic cells. It also plays a role in the translocation of calreticulin from plasma membrane.

Despite their overlapping biochemical functions, ERp57/PDIA3 displays significant differences in terms of length and arrangement. PDIA1 is the first member of the PDI family and is structurally characterized by two active thioredoxin-like domains and a substrate-binding domain along with an a'linker' sequence connecting the b' and a domain. The members of the PDIA family are also connected to glycoprotein folding in the ER. They regulate the disulfide bonding that allows for the folding of glycoproteins rich in cysteine.

The gene has been implicated in a wide range of tumors. But, ERp57/PDIA3 inhibition could be effective in reducing GB associated macrophages. PDIA3 inhibitors inhibit COX2 and IL1b synthesis and reduce their pro-inflammatory actions. While more research is required this protein could be a promising therapeutic strategy for GB.

ERp57/PDIA3 not only acts in different cell types , but also has multiple roles in human diseases. It interferes with SOD1 aggregates and mixed disulfide crosslinking, which are the most important components of the prion-infection process. It also regulates the production of prion proteins. Therefore, it is essential to discover ways to inhibit or inhibit the activity of ERp57/PDIA3 and discover treatments for it.

ALS has been connected to ERp57/PDIA3. Numerous research studies have demonstrated that ERp57/PDIA3 plays a role in ER stress pathways, which are responsible for the development of diseases like Alzheimer's disease. It is believed to interact with the vitamin D3 receptor, which is responsible for its involvement in ALS. In reality, ERp57/PDIA3 plays an impact on various cancers, including Parkinson's disease.

It is important to learn more about the role of the ERp57/PDIA3 gene in human fertility. The inhibition of ERp57/PDIA3 can block mTOR, decrease the phosphorylation of 4E-BP1 and block cross-talk between microglia. The role of ERp57/PDIA3 in the capacitation of sperm is a potential possibility for a contraceptive drug.

It is for research purposes only.

"It is intended for research use" (RUO) refers to the stage of development at which a product isn't yet ready to sell. It can also refer to products for in vitro diagnostics that are in the laboratory research stage. They are not approved for medical practice. The manufacturers of these products must make sure that their products do not contain any harmful substances that could harm patients. There is no one-size-fits-all definition for RUO products.

Many products that contain RNAi can be labeled RUO, which means they are not suitable for commercial distribution. They must therefore be labeled correctly to ensure that the product is safe for use by qualified personnel. This will help avoid any risk of liability if the reagent is misused. Labeling RUO products with "general laboratory equipment" can help to avoid legal issues. However, this approach could result in higher costs if used in clinical trials.