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- Table of Contents
PDIA6 Antibodies
AND PDIA6 ELISA kits, PDIA6 Proteins
Many biological assays use antibodies to detect PDIA6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDIA6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDIA6 antibodies...
Designing a Western blot for PDIA6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PDIA6 Western Blot GuideDesigning an IHC experiment for PDIA6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PDIA6 IHC GuidePDIA6 Infographic by Boster Bio
All PDIA6 Products
Product
Figures
Specificity
Applications
Price
Anti-PDIA6 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03813-2
100 μg/vial
Cat # A03813-2
100 μg/vial
Human, Monkey
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03813-1
100 μg/vial
Cat # M03813-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M03813
100 μl
Cat # M03813
100 μl
PDIA6 Overview
Facts about Protein disulfide-isomerase A6.
Protein disulfide-isomerase A6 (PDIA6)
May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390).
May also regulate the UPR through the EIF2AK3 UPR detector (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).
Gene Information
| Human | |
|---|---|
| Gene Name: | PDIA6 |
| Uniprot: | Q15084 |
| Entrez: | 10130 |
Family
| Belongs to: |
|---|
| protein disulfide isomerase family |
Alternative Names
EC 5.3.4.1; Endoplasmic reticulum protein 5; ERp5; ERP5ER protein 5; P5TXNDC7; protein disulfide isomerase family A, member 6; Protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; protein disulfide-isomerase A6; thioredoxin domain containing 7 (protein disulfide isomerase); Thioredoxin domain-containing protein 7
Molecular Weight
Mass (kDA):
48.121 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p25.1 |
| Sequence: | 2; NC_000002.12 (10783391..10837712, complement) |
Tissue Specificity
Expressed in platelets (at protein level).
Subcellular Localizations
Endoplasmic reticulum lumen. Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Physiological Stress
- Tumor Escape
- Cell Invasion
- Leukemia
- Melanoma
- Malignant Neoplasm Of Breast
- Dementia
- Ataxia
Interacting Proteins
- HSPA5
- PRDX4
Pathways
- Protein Folding
- Cell Migration
- Translation
- Cell Death
- Secretion
- Gene Silencing
- Tricarboxylic Acid Cycle
- Protein Alkylation
- Immune Response
- Platelet Activation
- Cell Cycle Arrest
- Platelet Aggregation
- Cell Division
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDIA6
bosterbio.com/bosterbio-gene-info-cards/PDIA6
References
PMID: 7590364 by Hayano T., et al. Cloning and sequencing of the cDNA encoding human P5.
PMID: 9110174 by Yu W., et al. Large-scale concatenation cDNA sequencing.