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- Table of Contents
Perm1 Antibodies
AND Perm1 ELISA kits, Perm1 Proteins
Many biological assays use antibodies to detect Perm1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Perm1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Perm1 antibodies...
Designing a Western blot for Perm1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PERM1 Western Blot GuidePerm1 Infographic by Boster Bio
All Perm1 Products
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Specificity
Applications
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Perm1 Overview
Facts about PGC-1 and ERR-induced regulator in muscle protein 1.
PGC-1 and ERR-induced regulator in muscle protein 1 (Perm1)
Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transport, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A.
Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively influences the PPARGC1A/ESRRG-induced expression of PDK4. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Perm1 |
| Uniprot: | Q149B8 |
| Entrez: | 74183 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
PGC-1 and ERR-induced regulator in muscle protein 1
Molecular Weight
Mass (kDA):
85.157 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4|4 E2 |
| Sequence: | 4; |
Tissue Specificity
Highly expressed in skeletal muscles and heart with lower levels in brown adipose tissue (at protein level). Muscle-specific expression is increased by endurance exercise.
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Perm1
bosterbio.com/bosterbio-gene-info-cards/Perm1
References
PMID: 23836911 by Cho Y., et al. Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC- 1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.