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- Table of Contents
Profilin-2 Antibodies
AND PFN2 ELISA kits, Profilin-2 Proteins
Many biological assays use antibodies to detect Profilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Profilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Profilin-2 antibodies...
Designing a Western blot for Profilin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PFN2 Western Blot GuideDesigning an IHC experiment for Profilin-2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PFN2 IHC GuidePFN2 Infographic by Boster Bio
All PFN2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A06663
100 μg/vial
Cat # A06663
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA2162
100 μg/vial
Cat # PA2162
100 μg/vial
PFN2 Overview
Facts about Profilin-2.
Profilin-2 (PFN2)
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
By binding to PIP2, it inhibits the formation of IP3 and DG. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PFN2 |
| Uniprot: | P35080 |
| Entrez: | 5217 |
Family
| Belongs to: |
|---|
| profilin family |
Alternative Names
D3S1319E; PFL; profilin 2; Profilin II; profilin-2
Molecular Weight
Mass (kDA):
15.046 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q25.1 |
| Sequence: | 3; NC_000003.12 (149964904..149970895, complement) |
Tissue Specificity
Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Subcellular Localizations
Cytoplasm, cytoskeleton.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Neoplasm Metastasis
- Diabetic Nephropathy
- Metastatic Malignant Neoplasm To The Lung
- Melanoma
- Tumor Progression
- Carcinoma
- Osteosarcoma
- Mouth Neoplasms
- Diseases In Twins
Interacting Proteins
- GOLGB1
- HTT
- Wasl
Pathways
- Localization
- Endocytosis
- Cell Motility
- Exocytosis
- Pathogenesis
- Transport
- Bioluminescence
- Mitosis
- Synaptic Transmission
- Spermatogenesis
- Cell Division
PTMs
- Phosphorylation
Research Areas
- Cell Biology
- Cellular Markers
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PFN2
bosterbio.com/bosterbio-gene-info-cards/PFN2
References
PMID: 8365484 by Honore B., et al. Cloning and expression of a novel human profilin variant, profilin II.
PMID: 11027290 by Lambrechts A., et al. Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties.