Profilin-2 Antibodies

AND PFN2 ELISA kits, Profilin-2 Proteins

Many biological assays use antibodies to detect Profilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Profilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Profilin-2 antibodies...

We validate the specificity of these antibodies to Profilin-2 by testing them on tissues known to express PFN2 positively and negatively. Browse below to find the PFN2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: CDK14

PFN2 Infographic by Boster Bio

All PFN2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Profilin 2/PFN2 Antibody Picoband®

4 Q&As

Western blot analysis of PFN2 using anti-PFN2 antibody (PA2162)

IHC analysis of PFN2 using anti-PFN2 antibody (PA2162)

IF analysis of PFN2 using anti-PFN2 antibody (PA2162)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PA2162
100 μg/vial

Anti-Profilin 2/PFN2 Antibody Picoband®

Western blot analysis of Profilin 2/PFN2 using anti-Profilin 2/PFN2 antibody (A06663)

IHC analysis of Profilin 2/PFN2 using anti-Profilin 2/PFN2 antibody (A06663)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A06663
100 μg/vial

Profilin 2 (PFN2) (NM_053024) Human Recombinant Protein

Coomassie blue staining of purified PFN2 protein

$1249
Cat # PROTP35080
20 µg

Profilin 2 (PFN2) (NM_053024) Human Over-expression Lysate

Profilin 2 (PFN2) Human Over-expression Lysates NM_002628

Human

$628
Cat # LS005217
20 µg, 100 µg

PFN2 Overview

Facts about Profilin-2.

PFN2 3D structure. Source: alphafold

Profilin-2 (PFN2)

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.

By binding to PIP2, it inhibits the formation of IP3 and DG. .

Gene Information

Human
Gene Name:	PFN2
Uniprot:	P35080
Entrez:	5217

Family

Belongs to:

profilin family

Alternative Names

D3S1319E; PFL; profilin 2; Profilin II; profilin-2

Molecular Weight

Mass (kDA):
15.046 kDA

Genomic Context


Human

Location:	3q25.1
Sequence:	3; NC_000003.12 (149964904..149970895, complement)

Tissue Specificity

Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.

Subcellular Localizations

Cytoplasm, cytoskeleton.

Diseases

Malignant Neoplasms
Neoplasms
Tissue Adhesions
Neoplasm Metastasis
Diabetic Nephropathy
Metastatic Malignant Neoplasm To The Lung
Melanoma
Tumor Progression
Carcinoma
Osteosarcoma
Mouth Neoplasms
Diseases In Twins

Nervousness
Spinal Muscular Atrophy
Dysequilibrium Syndrome
Bipolar Disorder
Malignant Squamous Cell Neoplasm
Mucinous Adenocarcinoma

Interacting Proteins

GOLGB1
HTT
Wasl

Pathways

Localization
Endocytosis
Cell Motility
Exocytosis
Pathogenesis
Transport
Bioluminescence
Mitosis
Synaptic Transmission
Spermatogenesis
Cell Division

Dna Replication
Mrna Splicing
Cell Cycle
Synaptic Vesicle Exocytosis
Inositol Phospholipid-mediated Signaling

PTMs

Phosphorylation

Cleavage

Research Areas

Cell Biology
Cellular Markers
Signal Transduction
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PFN2

References

PMID: 8365484 by Honore B., et al. Cloning and expression of a novel human profilin variant, profilin II.

PMID: 11027290 by Lambrechts A., et al. Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties.