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- Table of Contents
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1 Citations
Facts about Prohibitin.
As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
Human | |
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Gene Name: | PHB |
Uniprot: | P35232 |
Entrez: | 5245 |
Belongs to: |
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prohibitin family |
PHB; PHB1; Prohibitin
Mass (kDA):
29.804 kDA
Human | |
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Location: | 17q21.33 |
Sequence: | 17; NC_000017.11 (49404048..49414905, complement) |
Widely expressed in different tissues.
Mitochondrion inner membrane. Nucleus.
If you're looking for a Boster Bio, you've probably heard of its advantages and applications. But do you know the story of this biomarker? Learn more about its history and benefits as well as applications. The PHB Marker is an excellent tool for researchers, academics and business owners.
The advantages of a certain medicine are determined by checking the effectiveness of the treatment. PHB is a measure of shows the effectiveness of a medication in improving health and meeting the health needs of the public. The PHB measure is used by policymakers as well as other stakeholders to evaluate the effectiveness of a drug. A panel of 17 experts completes the evaluation. The panel examines three aspects of the drug's capability to improve health for the population and its ability to meet health-related needs of the public, and its impact on the healthcare system.
The PHB marker comes with many benefits. It is helpful in determining the potential for malignancy of the use of a drug. It has a high rate of predictive value of the recurrence. Furthermore, it has shown promising results in clinical trials. PHB-targeting therapies could play a significant role in the treatment of gliomas. In addition to predicting the malignant potential of a medication and its potential for malignancy, the PHB marker also has other advantages that could make it an attractive target for GBM treatment.
The PHB marker has been linked with the phosphorylation of ERK. PHB insufficiently can hinder the growth of GBC cells. When it is overexpressed, it increases cell growth and invasion. This indicates the role of the ERK pathway in the progression of GBC. It is important to remember that the presence of ERK is connected to the PHB marker. But that's not the only benefit of PHB.
Studies have shown that the silencing of PHB significantly reduced the synthesis of DNA in GBC cells. The data show that PHB-deficient mice do not show any significant apoptotic impact on GSC growth. It did however reduce the formation of tumorspheres. These results suggest that mice deficient in PHB might not be as vulnerable as they appear. This study is a step in the right direction. What are the benefits of PHB targeting therapy?
French scientist Lemoigne discovered polymers of hydroxybutyric acids, or PHB. Microbiologists today utilize PHB to detect taxonomic markers during their research. In the 1960s, however other types of PHAs were discovered , and PHA was given to them. PHAs have been the subject of recent interest among novel plastics researchers and have been backed by social forces.
Alongside cancer, PHB is expressed in other kinds of tumors as well. In rhabdoid tumors as well as immortalized fibroblasts, it triggers resistance to chemotherapy. Thus, therapies focused on reducing PHB overexpression might be useful for a variety of cancer. Here are some options for cancers resistant to chemotherapy. If you're interested to learn more about PHB and its role in various cancers, check out the following article!
Biparental BEN showed that a background of PHB has a direct impact on the rate of BEN. Paternal and maternal BEN also had an impact directly. Biparental BEN was 71.5 times more likely to occur in offspring than offspring with no background of BEN. Biparental BEN was associated with maternal history and biparental BEN. However paternal BEN did not have any direct impact on offspring's risk of developing the disorder.
The overexpression of PHB within the urine is associated with resistance to chemotherapy. Furthermore, overexpression of PHB impairs cytochrome c release, which is vital in the process of intrinsic apoptosis. PHB overexpression can influence mitochondrial morphogenesis, apoptotic priming, and mitochondrial morphogenesis. PHB measurements are crucial for finding resistance to chemotherapy. However, more research is needed to confirm this potential association.
Polyhydroxybutyrate (PHB) is a useful polymer that is used in a variety of industrial processes. It is a comparatively stiff and brittle polymer that has physical and chemical properties that are similar to polypropylene. It has many applications in medicine. PHB is biocompatible and can be used to detect tumors. It also enhances the quality of tissue engineering. The PHB marker is approved for use in a variety of applications.
PHB is a key player in cell proliferation, apoptosis, and senescence. It also regulates mitochondrial morphogenesis and helps to prevent oxidative stress-induced senescence. PHB expression decreases in a heterogeneous manner with age and it is found in numerous cellular compartments. Large quantities of PHB2 are located in the mitochondrial inner membrane. They control morphogenesis as well as DNA synthesizing.
In a recent study the phaA gene is inducible inside a potato seedling. It could produce 0.009 percent dwt PHB. Bohmert et al. further proved that the PHB gene can be targeted to the seed plastid through an expressor specific to seeds. For a variety of species of plants, the expression of PHB is observed to increase with genetic engineering.
PHB is involved in multiple signaling pathways. This includes activation of cell receptors and androgens. Therefore, PHB regulates gene expression in diverse cells, including spermatocytes. To further study this the possibility of transferring spermatocytes to PHB, they were transfected control shRNA and PHB shRNAs targeted at. The results from RNA sequencing showed that 519 genes had a significant difference in expression. Further analyses showed that PHB is particularly enriched for genes that belong to the JAK-STAT and PI3KAKT pathways.
A whitepaper on Phoenix Global (PHB) was published in July 2021. The company is a brand new entity that was established in 2020 as a result of the merger of Red Pulse Phoenix (APEX Network) and APEX Network. Phoenix is listed on four exchanges. It operates on the NEO blockchain. The PHB token is expected to become more well-known than Bitcoin in the future. Phoenix Global was the first company to make use of the NEO blockchain to value its tokens.
PMID: 1540973 by Sato T., et al. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.
PMID: 8244394 by Sato T., et al. The human prohibitin (PHB) gene family and its somatic mutations in human tumors.
*More publications can be found for each product on its corresponding product page