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- Table of Contents
PIAS4 Antibodies
AND PIAS4 ELISA kits, PIAS4 Proteins
Many biological assays use antibodies to detect PIAS4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIAS4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIAS4 antibodies...
Designing a Western blot for PIAS4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PIAS4 Western Blot GuideDesigning an IHC experiment for PIAS4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PIAS4 IHC GuidePIAS4 Infographic by Boster Bio
All PIAS4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PB10082
100 μg/vial
Cat # PB10082
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # PA2215
100 μg/vial
Cat # PA2215
100 μg/vial
Human, Mouse
ELISA
$480
Cat # EKC1459
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1459
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IHC-P, WB
$481
Cat # A02994
0.1 mg
Cat # A02994
0.1 mg
Human
$628
Cat # LS051588
20 µg, 100 µg
Cat # LS051588
20 µg, 100 µg
PIAS4 Overview
Facts about E3 SUMO-protein ligase PIAS4.
E3 SUMO-protein ligase PIAS4 (PIAS4)
Functions as an E3-type little ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a critical role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway.
Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIAS4 |
| Uniprot: | Q8N2W9 |
| Entrez: | 51588 |
Family
| Belongs to: |
|---|
| PIAS family |
Alternative Names
E3 SUMO-protein ligase PIAS4; FLJ12419; MGC35296; Piasg; PIAS-gamma; PIASY; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; protein inhibitor of activated STAT protein PIASy; protein inhibitor of activated STAT, 4; zinc finger, MIZ-type containing 6; ZMIZ6
Molecular Weight
Mass (kDA):
56.504 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (4007736..4039386) |
Tissue Specificity
Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes.
Subcellular Localizations
Nucleus, PML body. Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Diseases
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Carcinoma
- Malignant Neoplasm Of Breast
- Myeloid Leukemia
- Tumor Progression
- Cell Transformation, Neoplastic
- Tumor Angiogenesis
- Acute Promyelocytic Leukemia
- Mammary Neoplasms
- Dystrophy
- Inflammation
Interacting Proteins
- ESRRA
- HIF1A
- HTT
- PARP1
- RELA
- SUMO2
- TADA3
- TP53
Pathways
- Conjugation
- Localization
- Cell Cycle
- Cell Proliferation
- Senescence
- Gene Silencing
- Immune Response
- Chromosome Segregation
- Anaphase
- Inflammatory Response
- Reverse Transcription
- Tissue Remodeling
- Cell Growth
PTMs
- Sumoylation
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIAS4
bosterbio.com/bosterbio-gene-info-cards/PIAS4
References
PMID: 9724754 by Liu B., et al. Inhibition of Stat1-mediated gene activation by PIAS1.
PMID: 11388671 by Nelson V., et al. A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.