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- Table of Contents
PIK3CA Antibodies
AND PIK3CA ELISA kits, PIK3CA Proteins
Many biological assays use antibodies to detect PIK3CA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIK3CA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIK3CA antibodies...
Designing a Western blot for PIK3CA? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PIK3CA Western Blot GuidePIK3CA Infographic by Boster Bio
All PIK3CA Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, WB
$370
Cat # PB9314
100μg/vial
Cat # PB9314
100μg/vial
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # M00029
100 μl
Cat # M00029
100 μl
PIK3CA Overview
Facts about Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins into the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology.
Participates in cellular signaling in response to various growth factors. Involved in signaling through insulin-receptor substrate (IRS) proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIK3CA |
| Uniprot: | P42336 |
| Entrez: | 5290 |
Family
| Belongs to: |
|---|
| PI3/PI4-kinase family |
Alternative Names
EC 2.7.1; EC 2.7.1.153; MGC142161; MGC142163; p110-alpha; Phosphatidylinositol 3-Kinase catalytic subunit alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3K; PI3K-alpha; PI3-kinase p110 subunit alpha; PI3-kinase subunit alp
Molecular Weight
Mass (kDA):
124.284 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.32 |
| Sequence: | 3; NC_000003.12 (179148114..179240093) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Colorectal Cancer
- Colorectal Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Adenocarcinoma
- Malignant Squamous Cell Neoplasm
- Microsatellite Instability
- Malignant Neoplasm Of Lung
Interacting Proteins
- ERBB3
- IRS1
- PIK3R1
- PIK3R3
Pathways
- Pathogenesis
- Methylation
- Cell Proliferation
- Cell Growth
- Cell Cycle
- Angiogenesis
- Translation
- Dna Methylation
- Localization
- Senescence
- Drug Resistance
- Cell Death
- Mismatch Repair
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Dephosphorylation
Research Areas
- Breast Cancer
- Cancer
- Diabetes Research
- mTOR Pathway
- Oncogenes
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIK3CA
bosterbio.com/bosterbio-gene-info-cards/PIK3CA
References
PMID: 7713498 by Volinia S., et al. Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.
PMID: 9043658 by Stirdivant S.M., et al. Cloning and mutagenesis of the p110 alpha subunit of human phosphoinositide 3'-hydroxykinase.
1 Publications of Boster PIK3CA Antibodies & ELISA Kits
- PubMed ID: 25352008, Wang Q, Sun X, Li X, Dong X, Li P, Zhao L. Mol Med Rep. 2015 Jan;11(1):151-8. Do...
*More publications can be found for each product on its corresponding product page