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- Table of Contents
Peroxiredoxin-4 Antibodies
AND PRDX4 ELISA kits, Peroxiredoxin-4 Proteins
Many biological assays use antibodies to detect Peroxiredoxin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Peroxiredoxin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Peroxiredoxin-4 antibodies...
Designing a Western blot for Peroxiredoxin-4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRDX4 Western Blot GuideDesigning an IHC experiment for Peroxiredoxin-4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PRDX4 IHC GuidePRDX4 Infographic by Boster Bio
All PRDX4 Products
Product
Figures
Specificity
Applications
Price
Anti-Peroxiredoxin 4/PRDX4 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9383
100 μg/vial
Cat # PB9383
100 μg/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # M05000-1
100 μl/vial
Cat # M05000-1
100 μl/vial
Human
$628
Cat # LS010549
20 µg, 100 µg
Cat # LS010549
20 µg, 100 µg
PRDX4 Overview
Facts about Peroxiredoxin-4.
Peroxiredoxin-4 (PRDX4)
Thiol-specific peroxidase which catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as detector of hydrogen peroxide-mediated signaling events.
Regulates the activation of NF-kappa-B in the cytosol by a modulation of I- kappa-B-alpha phosphorylation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PRDX4 |
| Uniprot: | Q13162 |
| Entrez: | 10549 |
Family
| Belongs to: |
|---|
| peroxiredoxin family |
Alternative Names
Antioxidant enzyme AOE372; AOE372; AOE37-2PRX-4; EC 1.11.1.15; Peroxiredoxin 4; Peroxiredoxin IV; peroxiredoxin-4; PRDX4; Prx4; prx-4; prx-IV; thioredoxin peroxidase (antioxidant enzyme); Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372
Molecular Weight
Mass (kDA):
30.54 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.11 |
| Sequence: | X; NC_000023.11 (23667493..23686397) |
Subcellular Localizations
Cytoplasm. Endoplasmic reticulum. Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.
Diseases
- Malignant Neoplasms
- Neoplasms
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Carcinoma
- Adenocarcinoma
- Diabetes Mellitus
- Diabetes Mellitus, Experimental
- Carcinogenesis
- Malignant Neoplasm Of Lung
- Leukemia, Myelocytic, Acute
- Neoplasm Metastasis
Interacting Proteins
- LBP
- P4HB
- PDIA3
- PDIA6
- TBXA2R
- TXNDC5
Pathways
- Cell Migration
- Cell Differentiation
- Cell Proliferation
- Localization
- Cell Death
- Cell Growth
- Pathogenesis
- Secretion
- Cell Adhesion
- Protein Folding
- Rna Interference
- Programmed Cell Death
- Stem Cell Differentiation
PTMs
- Phosphorylation
- Oxidation
- Methylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRDX4
bosterbio.com/bosterbio-gene-info-cards/PRDX4
References
PMID: 9388242 by Jin D.-Y., et al. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation.
PMID: 19892738 by Xu G., et al. Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.