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- Table of Contents
PRMT5 Antibodies
AND PRMT5 ELISA kits, PRMT5 Proteins
Many biological assays use antibodies to detect PRMT5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRMT5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRMT5 antibodies...
Designing a Western blot for PRMT5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRMT5 Western Blot GuidePRMT5 Infographic by Boster Bio
All PRMT5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00635
100 μl
Cat # M00635
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00635-1
100 μg/vial
Cat # A00635-1
100 μg/vial
PRMT5 Overview
Facts about Protein arginine N-methyltransferase 5.
Protein arginine N-methyltransferase 5 (PRMT5)
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:21081503). Especially mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); these methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:12411503, PubMed:11747828, PubMed:17709427).
Methylates SUPT5H and might regulate its transcriptional elongation properties (PubMed:12718890). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRMT5 |
| Uniprot: | O14744 |
| Entrez: | 10419 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
EC 2.1.1.-; EC 2.1.1.125; Histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5,72 kDa ICln-binding protein; HRMT1L5; IBP72; Jak-binding protein 1; JBP1; protein arginine methyltransferase 5; protein arginine N-methyltransferase 5; Shk1 kinase-binding protein 1 homolog; skb1 (S. pombe) homolog; SKB1 homolog (S. pombe); SKB1; SKB1HsSKB1 homolog
Molecular Weight
Mass (kDA):
72.684 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (22920526..22929392, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Nucleus. Golgi apparatus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Lymphoma
- Retinoblastoma
- Myeloproliferative Disease
- Growth Retardation
- Spinal Muscular Atrophy
- Atrophy
- Janiceps
- Hyperplasia
- Lung Neoplasms
Interacting Proteins
- Ajuba
- CDYL2
- CLNS1A
- COPRS
- DNMT3A
- E2F1
- GRHL3
- GTPBP2
- HIST1H4A
- HOXA9
Pathways
- Methylation
- Localization
- Cell Proliferation
- Cell Cycle
- Cell Growth
- Rna Processing
- Histone Arginine Methylation
- Dna Methylation
- Protein Methylation
- Histone Methylation
- Chromatin Remodeling
- Dna Repair
- Translation
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Reduction
Research Areas
- Cell Cycle and Replication
- Chromatin Research
- Circadian Rhythm
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRMT5
bosterbio.com/bosterbio-gene-info-cards/PRMT5
References
PMID: 9556550 by Krapivinsky G., et al. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology.
PMID: 9843966 by Gilbreth M., et al. Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs.