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- Table of Contents
14 Citations 15 Q&As
11 Citations 4 Q&As
12 Citations 16 Q&As
12 Citations 16 Q&As
10 Citations 16 Q&As
Facts about Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN.
Also acts as a lipid phosphatase, removing the phosphate from the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is crucial for its tumor suppressor function.
Human | |
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Gene Name: | PTEN |
Uniprot: | P60484 |
Entrez: | 5728 |
Belongs to: |
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PTEN phosphatase protein family |
BZS; EC 3.1.3.16,10q23del; EC 3.1.3.48; EC 3.1.3.67; GLM2; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; MMAC1; MMAC1MGC11227; Mutated in multiple advanced cancers 1; phosphatase and tensin homologDEC; phosphatidylinositol-34,5-trisphosphate 3-phosphatase and dual-specificityprotein phosphatase PTEN; PTEN; PTEN1; TEP1MHAM
Mass (kDA):
47.166 kDA
Human | |
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Location: | 10q23.31 |
Sequence: | 10; NC_000010.11 (87863625..87971930) |
Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Cytoplasm. Nucleus. Nucleus, PML body. Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982).; [Isoform alpha]: Secreted. May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.
PMID: 9187108 by Li D.M., et al. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.
PMID: 9090379 by Steck P.A., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
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