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- Table of Contents
PTPN2 Antibodies
AND PTPN2 ELISA kits, PTPN2 Proteins
Many biological assays use antibodies to detect PTPN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN2 antibodies...
Designing a Western blot for PTPN2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PTPN2 Western Blot GuideDesigning an IHC experiment for PTPN2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PTPN2 IHC GuidePTPN2 Infographic by Boster Bio
All PTPN2 Products
Product
Figures
Specificity
Applications
Price
Anti-PTPN2 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse
Flow Cytometry, IP, WB
$370
Cat # M01597
100 μl/vial
Cat # M01597
100 μl/vial
Anti-TCPTP/PTPN2 Antibody Picoband®
1 Citations
Human, Rat
IF, IHC, ICC, WB
$370
Cat # PB9501
100 μg/vial
Cat # PB9501
100 μg/vial
PTPN2 Overview
Facts about Tyrosine-protein phosphatase non-receptor type 2.
Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)
Non-receptor type tyrosine-specific phosphatase which dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Additionally dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm.
Plays a multifaceted and important role in the maturation of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTPN2 |
| Uniprot: | P17706 |
| Entrez: | 5771 |
Family
| Belongs to: |
|---|
| protein-tyrosine phosphatase family |
Alternative Names
protein tyrosine phosphatase, non-receptor type 2; PTP2; PTPN2; PTPTPTN2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCELLPTP; TCPTP; TC-PTP; TCPTPEC 3.1.3.48; tyrosine-protein phosphatase non-receptor type 2
Molecular Weight
Mass (kDA):
48.473 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18p11.21 |
| Sequence: | 18; NC_000018.10 (12785478..12884351, complement) |
Tissue Specificity
Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta.
Subcellular Localizations
[Isoform 1]: Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region.; [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane.
Diseases
- Crohn Disease
- Diabetes Mellitus
- Diabetes Mellitus, Insulin-dependent
- Posttransfusion Purpura
- Autoimmune Reaction
- Autoimmune Diseases
- Colitis
- Ulcer
- Rheumatoid Arthritis
- Arthritis
- Ulcerative Colitis
- Autoimmunity
- Neoplasms
Interacting Proteins
- GHR
- TMED10
- TMED9
Pathways
- Pathogenesis
- Immune Response
- Secretion
- Cell Proliferation
- Cell Cycle
- Localization
- Autophagy
- Hyperphosphorylation
- Cell Adhesion
- Cytokine Secretion
- Rna Interference
- Gluconeogenesis
- Glucose Homeostasis
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN2
bosterbio.com/bosterbio-gene-info-cards/PTPN2
References
PMID: 2546150 by Cool D., et al. cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.
PMID: 1731319 by Mosinger B. Jr., et al. Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.