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- Table of Contents
Prohibitin-2 Antibodies
AND PHB2 ELISA kits, Prohibitin-2 Proteins
Many biological assays use antibodies to detect Prohibitin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prohibitin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prohibitin-2 antibodies...
Designing a Western blot for Prohibitin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PHB2 Western Blot GuideDesigning an IHC experiment for Prohibitin-2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PHB2 IHC GuidePHB2 Infographic by Boster Bio
All PHB2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M03315
100 μg/vial
Cat # M03315
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03315-3
100 μg/vial
Cat # A03315-3
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M03315-1
100 μl/vial
Cat # M03315-1
100 μl/vial
PHB2 Overview
Facts about Prohibitin-2.
Prohibitin-2 (PHB2)
Acts as a mediator of transcriptional repression by nuclear hormone receptors through recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator which potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens.
Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
Gene Information
| Human | |
|---|---|
| Gene Name: | PHB2 |
| Uniprot: | Q99623 |
| Entrez: | 11331 |
Family
| Belongs to: |
|---|
| prohibitin family |
Alternative Names
BAP; Bap37; BCAP37; B-cell associated protein; D-Prohibitin; MGC117268; p22; PHB2; PNAS-141; Prohibitin 2; prohibitin-2; REA; REAB-cell receptor-associated protein BAP37; Repressor of estrogen receptor activity
Molecular Weight
Mass (kDA):
33.296 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.31 |
| Sequence: | 12; NC_000012.12 (6965327..6970753, complement) |
Subcellular Localizations
Mitochondrion inner membrane. Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Liver Carcinoma
- Malignant Neoplasm Of Ovary
- Infective Disorder
- Cell Transformation, Neoplastic
- Obesity
- Follicular Cyst
- Optic Atrophy
- Neoplasm Metastasis
Interacting Proteins
- ESR1
Pathways
- Cell Proliferation
- Localization
- Senescence
- Aging
- Mitochondrial Fusion
- Transport
- Cell Cycle
- Rna Interference
- Electron Transport
- Proteolysis
- Replicative Senescence
- Cell Division
- Cellular Process
PTMs
- Phosphorylation
Research Areas
- Cellular Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PHB2
bosterbio.com/bosterbio-gene-info-cards/PHB2
References
PMID: 9074930 by Ansari-Lari M.A., et al. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
PMID: 10359819 by Montano M.M., et al. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.