This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
RAB5A Antibodies
AND RAB5A ELISA kits, RAB5A Proteins
Many biological assays use antibodies to detect RAB5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB5A antibodies...
Designing a Western blot for RAB5A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAB5A Western Blot GuideRAB5A Infographic by Boster Bio
All RAB5A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A01891
100 μg/vial
Cat # A01891
100 μg/vial
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01893-1
100 μg/vial
Cat # M01893-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01901-3
100 μg/vial
Cat # M01901-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M01891-1
100 μg/vial
Cat # M01891-1
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M01909-1
100 μg/vial
Cat # M01909-1
100 μg/vial
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # M01900-2
100 μg/vial
Cat # M01900-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M01900-3
100 μg/vial
Cat # M01900-3
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01891-2
20μL, 40μL, 100μL, 200μL
Cat # M01891-2
20μL, 40μL, 100μL, 200μL
RAB5A Overview
Facts about Ras-related protein Rab-5A.
Ras-related protein Rab-5A (RAB5A)
The little GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that's able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, motion, tethering and fusion.
RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216).
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB5A |
| Uniprot: | P20339 |
| Entrez: | 5868 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
RAB5A, member RAS oncogene family; RAB5RAS-associated protein RAB5A; ras-related protein Rab-5A
Molecular Weight
Mass (kDA):
23.659 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p24.3 |
| Sequence: | 3; NC_000003.12 (19947080..19985175) |
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Cytoplasmic vesicle. Cell projection, ruffle. Membrane. Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane. Endosome membrane. Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable).
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Adenocarcinoma
- Adenocarcinoma Of Lung (disorder)
- Cell Invasion
- Lung Neoplasms
- Tissue Adhesions
- Inflammation
- Non-small Cell Lung Carcinoma
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Breast
Interacting Proteins
- ALS2
- ANKFY1
- APPL1
- EEA1
- OCRL
- SUN2
Pathways
- Endocytosis
- Transport
- Localization
- Phagocytosis
- Receptor-mediated Endocytosis
- Secretion
- Exocytosis
- Intracellular Transport
- Cell Death
- Cell Migration
- Membrane Fusion
- Phagosome Maturation
- Cell Growth
PTMs
- Phosphorylation
- Glycosylation
- Geranylgeranylation
- Prenylation
- Ribosylation
Research Areas
- Endosome Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB5A
bosterbio.com/bosterbio-gene-info-cards/RAB5A
References
PMID: 2501306 by Zahraoui A., et al. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.
PMID: 7991565 by Farnsworth C.C., et al. Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.
1 Publications of Boster RAB5A Antibodies & ELISA Kits
- PubMed ID: 28491025, Han F, Jiang J, Ding J, Liu H, Xiao B, Shi Y. Front Behav Neurosci. 2017 Apr 26;...
*More publications can be found for each product on its corresponding product page