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RACK1 Antibodies
AND RACK1 ELISA kits, RACK1 Proteins
Many biological assays use antibodies to detect RACK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RACK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RACK1 antibodies...
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RACK1 Infographic by Boster Bio
All RACK1 Products
Product
Figures
Specificity
Applications
Price
Anti-RACK1 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02145-1
100 μl/vial
Cat # M02145-1
100 μl/vial
RACK1 Overview
Facts about Receptor of activated protein C kinase 1.
Receptor of activated protein C kinase 1 (RACK1)
Scaffolding protein involved in the recruitment, assembly and/or regulation of many different signaling molecules. Interacts with a huge selection of proteins and plays a role in many cellular processes.
Part of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved from the initiation of the ribosome quality control (RQC), a pathway that happens when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843).
Gene Information
| Human | |
|---|---|
| Gene Name: | RACK1 |
| Uniprot: | P63244 |
| Entrez: | 10399 |
Family
| Belongs to: |
|---|
| WD repeat G protein beta family |
Alternative Names
Receptor of activated protein C kinase 1
Molecular Weight
Mass (kDA):
35.077 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q35.3 |
| Sequence: | 5; NC_000005.10 (181236897..181243906, complement) |
Tissue Specificity
In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.
Subcellular Localizations
Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Perikaryon. Cell projection, dendrite. Cell projection, phagocytic cup. Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity).
Interacting Proteins
- ACHE
- ACTN2
- AGO2
- BCL2L11
- DYNLL1
- EED
- IFNAR2
- INCA1
- LARP4B
- LRP12
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RACK1
bosterbio.com/bosterbio-gene-info-cards/RACK1
References
PMID: 2499885 by Guillemot F., et al. Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex.
PMID: 9584165 by Chang B.Y., et al. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.