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- Table of Contents
RECK Antibodies
AND RECK ELISA kits, RECK Proteins
Many biological assays use antibodies to detect RECK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RECK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RECK antibodies...
Designing a Western blot for RECK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RECK Western Blot GuideDesigning an IHC experiment for RECK? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RECK IHC GuideRECK Infographic by Boster Bio
All RECK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A06442-2
100 µg/vial
Cat # A06442-2
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A06439-4
100 µg/vial
Cat # A06439-4
100 µg/vial
RECK Overview
Facts about Reversion-inducing cysteine-rich protein with Kazal motifs.
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)
Functions together with ADGRA2 to enable brain endothelial cells to respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific answers: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 into frizzled by building a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314).
Gene Information
| Human | |
|---|---|
| Gene Name: | RECK |
| Uniprot: | O95980 |
| Entrez: | 8434 |
Family
| Belongs to: |
|---|
| RECK family |
Alternative Names
hRECK; membrane-anchored glycoprotein (metastasis and invasion); RECK; reversion-inducing-cysteine-rich protein with kazal motifs; ST15; ST15reversion-inducing cysteine-rich protein with Kazal motifs; suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein withkazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein withkazal motifs); Suppressor of tumorigenicity 15 protein
Molecular Weight
Mass (kDA):
106.457 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.3 |
| Sequence: | 9; NC_000009.12 (36036905..36124455) |
Tissue Specificity
Expressed in various tissues and untransformed cells (PubMed:9789069). It is undetectable in tumor-derived cell lines and oncogenically transformed cells (PubMed:9789069).
Subcellular Localizations
Cell membrane; Lipid-anchor, GPI-anchor.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Carcinoma
- Tumor Angiogenesis
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Carcinogenesis
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Pathologic Neovascularization
Interacting Proteins
- ERBB2
Pathways
- Angiogenesis
- Cell Proliferation
- Secretion
- Methylation
- Cell Migration
- Pathogenesis
- Proteolysis
- Localization
- Cell Adhesion
- Gene Silencing
- Tube Formation
- Cell Cycle
- Vasculogenesis
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Demethylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RECK
bosterbio.com/bosterbio-gene-info-cards/RECK
References
PMID: 9789069 by Takahashi C., et al. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.
PMID: 18194466 by Chang C.K., et al. The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo.
3 Publications of Boster RECK Antibodies & ELISA Kits
- PubMed ID: 10.1177/15353702211035689, Delivery of microRNA-21-sponge and pre-microRNA-122 by MS2 virus-like particles ...
- PubMed ID: 10.1016/j.mcp.2020.101572, miR-544a Stimulates endometrial carcinoma growth via targeted inhibition of reve...
- PubMed ID: 32525042, Zheng WP,Meng FL,Wang LY.miR-544a Stimulates endometrial carcinoma growth via ta...
*More publications can be found for each product on its corresponding product page