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- Table of Contents
RFC1 Antibodies
AND RFC1 ELISA kits, RFC1 Proteins
Many biological assays use antibodies to detect RFC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RFC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RFC1 antibodies...
Designing a Western blot for RFC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RFC1 Western Blot GuideRFC1 Infographic by Boster Bio
All RFC1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1716
100 μg/vial
Cat # PA1716
100 μg/vial
Anti-SLC19A1 Antibody Picoband®
2 Citations
Human, Monkey, Mouse, Rat
WB
$370
Cat # PB9504
100 μg/vial
Cat # PB9504
100 μg/vial
RFC1 Overview
Facts about Replication factor C subunit 1.
Replication factor C subunit 1 (RFC1)
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction.
Binds the PO-B transcription component in addition to other GA rich DNA sequences. Could play a role in DNA transcription regulation in addition to DNA replication and/or repair.
Gene Information
| Human | |
|---|---|
| Gene Name: | RFC1 |
| Uniprot: | P35251 |
| Entrez: | 5981 |
Family
| Belongs to: |
|---|
| activator 1 large subunit family |
Alternative Names
A1 140 kDa subunit; A1; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; MGC51786; MHC binding factor, beta; MHCBFB; PO-GA; RECC1; replication factor C (activator 1) 1 (145kD); replication factor C (activator 1) 1, 145kDa; Replication factor C 140 kDa subunit; Replication factor C large subunit; replication factor C subunit 1; replication factor C1; RF-C 140 kDa subunit; RFC; RFC1; RFC140; RFC140DNA-binding protein PO-GA
Molecular Weight
Mass (kDA):
128.255 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p14 |
| Sequence: | 4; NC_000004.12 (39287456..39366381, complement) |
Tissue Specificity
Wide tissue distribution. Undetectable in placental tissue.
Subcellular Localizations
Nucleus.
Diseases
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Malignant Neoplasms
- Leukemia
- Acute Lymphocytic Leukemia
- Neoplasms
- Malignant Neoplasm Of Breast
- L1 Acute Lymphoblastic Leukemia
- Leukemia L1210
- Folic Acid Deficiency
- Congenital Abnormality
- Mammary Neoplasms
- Carcinoma
- Cleft Palate
Interacting Proteins
- RFC2
Pathways
- Transport
- Dna Replication
- Dna Repair
- Cell Cycle
- Methylation
- Dna Damage Checkpoint
- Dna Methylation
- S Phase
- Localization
- Drug Resistance
- Cell Proliferation
- Mismatch Repair
- Sister Chromatid Cohesion
PTMs
- Methylation
- Phosphorylation
- Reduction
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RFC1
bosterbio.com/bosterbio-gene-info-cards/RFC1
References
PMID: 8248204 by Bunz F., et al. cDNAs encoding the large subunit of human replication factor C.
PMID: 8512577 by Lu Y., et al. Cloning and expression of a novel human DNA binding protein, PO-GA.
2 Publications of Boster RFC1 Antibodies & ELISA Kits
- PubMed ID: , SLC19A1 transports immunoreactive cyclic dinucleotides
- PubMed ID: 31511694 , SLC19A1 transports immunoreactive cyclic dinucleotides
*More publications can be found for each product on its corresponding product page