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GTP-binding protein Rheb Antibodies
AND RHEB ELISA kits, GTP-binding protein Rheb Proteins
Many biological assays use antibodies to detect GTP-binding protein Rheb, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GTP-binding protein Rheb in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GTP-binding protein Rheb antibodies...
Designing a Western blot for GTP-binding protein Rheb? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RHEB Western Blot GuideDesigning an IHC experiment for GTP-binding protein Rheb? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RHEB IHC GuideRHEB Infographic by Boster Bio
All RHEB Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00827-1
100 μl/vial
Cat # M00827-1
100 μl/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A00827-1
0.1 mg
Cat # A00827-1
0.1 mg
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$405
Cat # A00827-2
100ul
Cat # A00827-2
100ul
RHEB Overview
Facts about GTP-binding protein Rheb.
GTP-binding protein Rheb (RHEB)
Activates the protein kinase activity of mTORC1, and thus plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling.
Has low intrinsic GTPase activity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RHEB |
| Uniprot: | Q15382 |
| Entrez: | 6009 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
GTP-binding protein Rheb; MGC111559; Ras homolog enriched in brainRHEB2Ras homolog enriched in brain 2; Rheb; Rheb2
Molecular Weight
Mass (kDA):
20.497 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q36.1 |
| Sequence: | 7; NC_000007.14 (151466012..151519895, complement) |
Tissue Specificity
Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
Subcellular Localizations
Endomembrane system; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.
Diseases
- Tuberous Sclerosis
- Sclerosis
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Lymphangioleiomyomatosis
- Hereditary Diseases
- Hamartoma
- Benign Neoplasm
- Angiomyolipoma
- Insulin Resistance
- Diabetes Mellitus
- Obesity
Interacting Proteins
- MTOR
- PDE6D
- PLD1
- TPT1
Pathways
- Cell Growth
- Translation
- Cell Cycle
- Autophagy
- Localization
- Pathogenesis
- Cell Proliferation
- Cell Death
- Senescence
- Regulation Of Cell Growth
- Hyperphosphorylation
- Transport
- Secretion
PTMs
- Phosphorylation
- Farnesylation
- Cleavage
- Prenylation
- Geranylgeranylation
- Acetylation
Research Areas
- Cancer
- mTOR Pathway
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RHEB
bosterbio.com/bosterbio-gene-info-cards/RHEB
References
PMID: 8543055 by Gromov P.S., et al. A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb.
PMID: 8661031 by Mizuki N., et al. Isolation of cDNA and genomic clones of a human Ras-related GTP- binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36.