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- Table of Contents
RIPK3 Antibodies
AND RIPK3 ELISA kits, RIPK3 Proteins
Many biological assays use antibodies to detect RIPK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RIPK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RIPK3 antibodies...
Designing a Western blot for RIPK3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RIPK3 Western Blot GuideRIPK3 Infographic by Boster Bio
All RIPK3 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA, IP, IF, WB
$146
Cat # M00202-2
20μL, 40μL, 100μL, 200μL
Cat # M00202-2
20μL, 40μL, 100μL, 200μL
Mouse, Rat
IF, ICC, WB
$370
Cat # M00202-3
100 μl/vial
Cat # M00202-3
100 μl/vial
RIPK3 Overview
Facts about Receptor-interacting serine/threonine-protein kinase 3.
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
Critical for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complicated.
RIPK3 binds to and enhances the action of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes can eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Gene Information
| Human | |
|---|---|
| Gene Name: | RIPK3 |
| Uniprot: | Q9Y572 |
| Entrez: | 11035 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11.1; Receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; RIP3; RIP-3; RIP3receptor interacting protein 3; RIPK3; RIP-like protein kinase 3
Molecular Weight
Mass (kDA):
56.887 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q12 |
| Sequence: | 14; NC_000014.9 (24336025..24339991, complement) |
Tissue Specificity
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
Subcellular Localizations
Cytoplasm, cytosol. Cell membrane. Mitochondrion.
Diseases
- Inflammation
- Malignant Neoplasms
- Virus Diseases
- Neoplasms
- Infective Disorder
- Cytomegalovirus Infections
- Cell Transformation, Neoplastic
- Reperfusion Injury
- Inflammatory Response
- Nerve Degeneration
- Carcinoma
- Tissue Damage
Interacting Proteins
- BIRC2
- BIRC3
- MLKL
- RIPK1
- ZBP1
Pathways
- Cell Death
- Necroptosis
- Pathogenesis
- Programmed Cell Death
- Necrotic Cell Death
- Immune Response
- Autophagy
- Cell Cycle
- Localization
- Inflammatory Response
- Cell Proliferation
- Methylation
- Rna Interference
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
Research Areas
- Cancer
- Cell Biology
- Immunology
- Necroptosis
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RIPK3
bosterbio.com/bosterbio-gene-info-cards/RIPK3
References
PMID: 10339433 by Yu P.W., et al. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.
PMID: 10358032 by Sun X., et al. RIP3, a novel apoptosis-inducing kinase.
1 Publications of Boster RIPK3 Antibodies & ELISA Kits
- PubMed ID: -, Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Pro...
*More publications can be found for each product on its corresponding product page