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- Table of Contents
Protein CBFA2T1 Antibodies
AND RUNX1T1 ELISA kits, Protein CBFA2T1 Proteins
Many biological assays use antibodies to detect Protein CBFA2T1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein CBFA2T1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein CBFA2T1 antibodies...
Designing a Western blot for Protein CBFA2T1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RUNX1T1 Western Blot GuideDesigning an IHC experiment for Protein CBFA2T1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RUNX1T1 IHC GuideRUNX1T1 Infographic by Boster Bio
All RUNX1T1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A01792-1
100 μg/vial
Cat # A01792-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01793-2
100 μg/vial
Cat # A01793-2
100 μg/vial
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01794-3
100 μg/vial
Cat # A01794-3
100 μg/vial
RUNX1T1 Overview
Facts about Protein CBFA2T1.
Protein CBFA2T1 (RUNX1T1)
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of additional corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | RUNX1T1 |
| Uniprot: | Q06455 |
| Entrez: | 862 |
Family
| Belongs to: |
|---|
| CBFA2T family |
Alternative Names
AML1T1protein CBFA2T1; CBFA2T1Cyclin-D-related protein; CDRMGC2796; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclinD-related; DKFZp564B213; Eight twenty one protein; ETOFLJ33145; MTG8acute myelogenous leukemia 1 translocation 1, cyclin-D related; Protein ETO; Protein MTG8; runt-related transcription factor 1; translocated to, 1 (cyclin D-related); Zinc finger MYND domain-containing protein 2; ZMYND2myeloid translocation gene on 8q22
Molecular Weight
Mass (kDA):
67.566 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q21.3 |
| Sequence: | 8; NC_000008.11 (91954967..92103451, complement) |
Tissue Specificity
Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
Subcellular Localizations
Nucleus. Colocalizes with ATN1 in discrete nuclear dots.
Diseases
- Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Chromosomal Translocation
- T(8;21)(q22;q22)
- Leukemogenesis
- Cytogenetic Abnormality
- Malignant Neoplasms
- Neoplasms
- Nervousness
- Neoplasm, Residual
- Cell Transformation, Neoplastic
Interacting Proteins
- ABI3
- C19orf57
- CCDC36
- CPSF7
- CREB3L1
- EFHC2
- EPS8
- GSE1
- HOMER3
- LPXN
Pathways
- Pathogenesis
- Localization
- Cell Differentiation
- Interphase
- Methylation
- Cell Growth
- Cell Proliferation
- Cell Cycle
- Histone Acetylation
- Segmentation
- Metaphase
- Myeloid Cell Differentiation
- Senescence
PTMs
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RUNX1T1
bosterbio.com/bosterbio-gene-info-cards/RUNX1T1
References
PMID: 8334990 by Miyoshi H., et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.
PMID: 9661669 by Wolford J.K., et al. Structure and expression of the human MTG8/ETO gene.