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- Table of Contents
RUNX3 Antibodies
AND RUNX3 ELISA kits, RUNX3 Proteins
Many biological assays use antibodies to detect RUNX3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RUNX3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RUNX3 antibodies...
Designing a Western blot for RUNX3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RUNX3 Western Blot GuideDesigning an IHC experiment for RUNX3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RUNX3 IHC GuideRUNX3 Infographic by Boster Bio
All RUNX3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9432
100 μg/vial
Cat # PB9432
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00086
100 μl
Cat # M00086
100 μl
RUNX3 Overview
Facts about Runt-related transcription factor 3.
Runt-related transcription factor 3 (RUNX3)
Types the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA- binding regulatory subunit that allosterically enriches the sequence-specific DNA-binding capacity of RUNX.
May be involved in the control of cellular proliferation and/or distinction. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712).
Gene Information
| Human | |
|---|---|
| Gene Name: | RUNX3 |
| Uniprot: | Q13761 |
| Entrez: | 864 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Acute myeloid leukemia 2 protein; AML2; AML2SL3/AKV core-binding factor alpha C subunit; CBFA3; CBFA3MGC16070; CBF-alpha-3; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2A3; PEBP2A3FLJ34510; PEBP2AC; PEBP2-alpha C; runt domain, alpha subunit 3; runt-related transcription factor 3; RUNX3; SL3-3 enhancer factor 1 alpha C subunit; transcription factor AML2
Molecular Weight
Mass (kDA):
44.356 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (24899511..24965158, complement) |
Tissue Specificity
Expressed in gastric cancer tissues (at protein level).
Subcellular Localizations
Nucleus. Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Stomach
- Carcinoma
- Stomach Neoplasms
- Carcinogenesis
- Cell Transformation, Neoplastic
- Colorectal Cancer
- Adenocarcinoma
- Colorectal Neoplasms
- Neoplasm Metastasis
- Microsatellite Instability
- Leukemia
Interacting Proteins
- BRD2
- CTNNB1
- EP300
- HDAC4
- HDAC5
- TCF7L2
- TLE1
Pathways
- Methylation
- Dna Methylation
- Pathogenesis
- Cell Proliferation
- Cell Differentiation
- Gene Silencing
- Cell Growth
- Cell Cycle
- Neurogenesis
- Localization
- Cell Development
- Chondrocyte Differentiation
- Dna Hypermethylation
PTMs
- Methylation
- Demethylation
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RUNX3
bosterbio.com/bosterbio-gene-info-cards/RUNX3
References
PMID: 7622058 by Bae S.-C., et al. Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.
PMID: 7835892 by Levanon D., et al. AML1, AML2, and AML3, the human members of the runt domain gene- family: cDNA structure, expression, and chromosomal localization.