SELPLG Antibodies

P-selectin glycoprotein ligand 1 (SELPLG)

A SLe(x)-type proteoglycan, which through substantial affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

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Gene Information

Human
Gene Name:	SELPLG
Uniprot:	Q14242
Entrez:	6404

Family

Belongs to:
No superfamily

Alternative Names

CD162 antigen; CD162; P-selectin glycoprotein ligand 1; PSGL1; PSGL-1; PSGL-1cutaneous lymphocyte-associated associated antigen; selectin P ligandCLA; SELPLG

Molecular Weight

Mass (kDA):
43.201 kDA

Genomic Context

Human
Location:	12q24.11
Sequence:	12; NC_000012.12 (108621895..108633894, complement)

Tissue Specificity

Expressed on neutrophils, monocytes and most lymphocytes.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Tissue Adhesions
• Atherosclerosis
• Coronary Artery Disease
• Inflammatory Response
• Cardiovascular Diseases
• Lymphoma
• Cardiac Death
• Sclerosis
• Stenosis
• Infarction
• Down Syndrome
• Sarcoma

• Venous Thrombosis
• Variable Number Tandem Repeat
• Myocardial Infarction
• Malignant Neoplasms
• Primary Effusion Lymphoma
• Pertussis

Interacting Proteins

• SELP
• SNX20

Pathways

• Pathogenesis
• Inflammatory Response
• Cell Adhesion
• Cell Migration
• Immune Response
• Metaphase
• Localization
• Methylation
• Chemotaxis

• Coagulation
• Cell Motility
• Integrin Activation
• Interphase

PTMs

• Methylation

Research Areas

• Cholesterol Metabolism
• Immunology
• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SELPLG

Best Uses of the SELPLG Marker

Are you searching for information on Boster Bio? If so, you have come to the right spot. This article will concentrate on Boster Bio and the SELPLG protein-coding gene. We will also discuss the many uses for this gene. These genes are beneficial to scientists of all levels and can be used to serve a variety of purposes. So, let's get started! Here are the most effective uses of the SELPLG gene marker.

Boster Bio

Both PPBP as well as SELPLG have been proven to be effective in predicting the decline of a patient's condition. But which one was more effective in predicting the likelihood of clinical worsening? The cutoff that was the most effective was 100 percent for NPV as well as PPV. This article will analyze PPBP and SELPLG to help with this. It is important that both the cutoff values for each test are different.

As SELPLG is thought to play a role in regulating hemostasis. The present study offers insights into the significance of platelets in the development of disease severity. It also uncovers a distinct sign of hemostasis in critically ill patients. It also detects an indicator that is soluble (sP-selectin) that was associated with mortality in hospitals. A significant negative correlation was found between elevated SELPLG or PPBP RNA levels and the need for mechanical ventilation.

SELPLG is a protein coding genes

The SELPLG is a protein-coding gene that encodes P-selectin glycoprotein ligand 1. The selectin pathway plays a critical role in the transmigration of leukocytes. Preclinical studies of ARDS revealed that mice with genetically engineered SELPLG gene were less likely than others to suffer lung damage from LPS exposure. In addition, mice with an anti-PSGL-1 neutralizing antibody showed less lung damage in the lung model of LPS-induced ARDS.

The SELPLG protein coding gene is a novel therapeutic target for ARDS and is a candidate for treatment. This gene codes for P–selectin Glycoprotein Ligand 1. It is a unique therapeutic target for ARDS. The SELPLG gene which is both complex and highly conserved, demands the immediate attention of an experienced intensive-care specialist. The SELPLG study protocol was approved by the University of Arizona's Institutional Review Board.

This study has revealed that SELPLG may be a novel susceptibility gene to ARDS. This gene has been studied in African and European populations. Some preliminary results have been published in abstracts. To determine if SELPLG enhances the likelihood of developing the disease, further research is needed. Although these findings are encouraging however, they aren't conclusive. These results raise the issue of whether the SELPLG could be used as a biomarker in the treatment of ARDS.

PSGL-1, also known as Selectin P ligand, is a disulfide-linked homodimer. It is a high affinity counter-receptor for P-selectin and plays a critical function in tying cells to activated platelets and endothelia that express Pselectin. And as we all know, there are many types of leukocytes and PSGL-1 is one of them.