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- Table of Contents
SETDB2 Antibodies
AND SETDB2 ELISA kits, SETDB2 Proteins
Many biological assays use antibodies to detect SETDB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SETDB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SETDB2 antibodies...
Designing a Western blot for SETDB2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SETDB2 Western Blot GuideSETDB2 Infographic by Boster Bio
All SETDB2 Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A08290-3
100 μg/vial
Cat # A08290-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # A08290-2
100 μg/vial
Cat # A08290-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A08310-1
100 µg/vial
Cat # A08310-1
100 µg/vial
SETDB2 Overview
Facts about Histone-lysine N-methyltransferase SETDB2.
Histone-lysine N-methyltransferase SETDB2 (SETDB2)
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Especially trimethylates'Lys-9' of histone H3 (H3K9me3).
H3K9me3 is a particular tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats.
Gene Information
| Human | |
|---|---|
| Gene Name: | SETDB2 |
| Uniprot: | Q96T68 |
| Entrez: | 83852 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
C13orf4; chromosome 13 open reading frame 4; chronic lymphocytic leukemia deletion region 8; Chronic lymphocytic leukemia deletion region gene 8 protein; CLLD8DKFZp761J1217; DKFZp586I0123; EC 2.1.1.43; histone-lysine N-methyltransferase SETDB2; KMT1FCLLL8; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SET domain, bifurcated 2
Molecular Weight
Mass (kDA):
81.894 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.2 |
| Sequence: | 13; NC_000013.11 (49444274..49495003) |
Tissue Specificity
Ubiquitous. Highest expression in heart, testis and ovary.
Subcellular Localizations
Nucleus. Chromosome.
Diseases
- Asthma
- Rhinorrhea
- Dermatitis
- Rett Syndrome
- Dermatitis, Atopic
- Developmental Delay (disorder)
- Childhood Asthma
- Carcinogenesis
- Epilepsy
- Childhood Atopic Dermatitis
- Allergic Rhinitis (disorder)
- Autistic Disorder
Interacting Proteins
- ARL14EP
Pathways
- Methylation
- Mitosis
- Viral Transcription
- Sister Chromatid Cohesion
- Cell Differentiation
- Chromosome Condensation
- Chromosome Segregation
- Meiosis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SETDB2
bosterbio.com/bosterbio-gene-info-cards/SETDB2
References
PMID: 11306461 by Mabuchi H., et al. Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.
PMID: 20404330 by Falandry C., et al. CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation.