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14-3-3 protein sigma Antibodies
AND SFN ELISA kits, 14-3-3 protein sigma Proteins
Many biological assays use antibodies to detect 14-3-3 protein sigma, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 14-3-3 protein sigma in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 14-3-3 protein sigma antibodies...
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SFN Infographic by Boster Bio
All SFN Products
Product
Figures
Specificity
Applications
Price
Anti-14-3-3 sigma/SFN Antibody Picoband®
3 Citations 7 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1797
100 μg/vial
Cat # PA1797
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01127
100 μg/vial
Cat # A01127
100 μg/vial
SFN Overview
Facts about 14-3-3 protein sigma.
14-3-3 protein sigma (SFN)
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | SFN |
| Uniprot: | P31947 |
| Entrez: | 2810 |
Family
| Belongs to: |
|---|
| 14-3-3 family |
Alternative Names
14-3-3 protein sigma; 1433 sigma; 14-3-3 sigma; Epithelial cell marker protein 1; HME1; SFN; stratifin; YWHAS
Molecular Weight
Mass (kDA):
27.774 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (26863149..26864456) |
Tissue Specificity
Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Subcellular Localizations
Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Carcinogenesis
- Malignant Neoplasm Of Prostate
- Neoplasm Metastasis
- Adenocarcinoma
- Prostatic Neoplasms
- Malignant Squamous Cell Neoplasm
Interacting Proteins
- ABL1
- AJUBA
- ARAF
- BAD
- CCDC102B
- CCNH
- COP1
- COPS6
- EGFR
- ERRFI1
Pathways
- Cell Cycle
- Methylation
- Cell Cycle Arrest
- Cell Proliferation
- Cell Death
- Cell Growth
- Dna Methylation
- Induction Of Apoptosis
- Pathogenesis
- Dna Repair
- Localization
- Mitosis
- Wound Healing
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SFN
bosterbio.com/bosterbio-gene-info-cards/SFN
References
PMID: 1390337 by Prasad G.L., et al. Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.
PMID: 8515476 by Leffers H., et al. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.
2 Publications of Boster 14-3-3 protein sigma Antibodies & ELISA Kits
- PubMed ID: 18198183, Makorin-2 Is a Neurogenesis Inhibitor Downstream of Phosphatidylinositol\n 3-Kin...
- PubMed ID: 25523932, Xu Lx, Li Zh, Tao Yf, Li Rh, Fang F, Zhao H, Li G, Li Yh, Wang J, Feng X, Pan J....
*More publications can be found for each product on its corresponding product page