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Shugoshin 2 Antibodies
AND SGO2 ELISA kits, Shugoshin 2 Proteins
Many biological assays use antibodies to detect Shugoshin 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Shugoshin 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Shugoshin 2 antibodies...
Designing an IHC experiment for Shugoshin 2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SGO2 IHC GuideSGO2 Infographic by Boster Bio
All SGO2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A08632
100 μg/vial
Cat # A08632
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2110
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2110
1 kit, containing two 96-well plates and all necessary reagents
SGO2 Overview
Facts about Shugoshin 2.
Shugoshin 2 (SGO2)
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes especially during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase.
During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus vital for an accurate gametogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | SGO2 |
| Uniprot: | Q562F6 |
| Entrez: | 151246 |
Family
| Belongs to: |
|---|
| shugoshin family |
Alternative Names
Shugoshin 2
Molecular Weight
Mass (kDA):
144.739 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.1 |
| Sequence: | 2; NC_000002.12 (200510198..200584096) |
Subcellular Localizations
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at
Interacting Proteins
- CDCA8
- MAD2L1
- MAD2L1BP
- PPP1CA
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGO2
bosterbio.com/bosterbio-gene-info-cards/SGO2
References
PMID: 16541025 by Kitajima T.S., et al. Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
PMID: 17485487 by Huang H., et al. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.