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- Table of Contents
Endophilin-A1 Antibodies
AND SH3GL2 ELISA kits, Endophilin-A1 Proteins
Many biological assays use antibodies to detect Endophilin-A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Endophilin-A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Endophilin-A1 antibodies...
Designing a Western blot for Endophilin-A1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SH3GL2 Western Blot GuideDesigning an IHC experiment for Endophilin-A1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SH3GL2 IHC GuideSH3GL2 Infographic by Boster Bio
All SH3GL2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05430-2
100 μg/vial
Cat # A05430-2
100 μg/vial
SH3GL2 Overview
Facts about Endophilin-A1.
Endophilin-A1 (SH3GL2)
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.
Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Gene Information
| Human | |
|---|---|
| Gene Name: | SH3GL2 |
| Uniprot: | Q99962 |
| Entrez: | 6456 |
Family
| Belongs to: |
|---|
| endophilin family |
Alternative Names
CNSA2; CNSA2FLJ25015; EEN-B1; EEN-B1bA335L15.1 (SH3-domain GRB2-like 2); Endophilin A1; Endophilin-1; endophilin-A1; FLJ20276; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3D2A; SH3D2AEndophilin A1 BAR domain; SH3-domain GRB2-like 2; SH3GL2; SH3P4; SH3P4endophilin-1
Molecular Weight
Mass (kDA):
39.962 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p22.2 |
| Sequence: | 9; NC_000009.12 (17579066..17797124) |
Tissue Specificity
Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Neurodegenerative Disorders
- Malignant Squamous Cell Neoplasm
- Neoplasm Metastasis
- Laryngeal Neoplasm
- Carcinogenesis
- Laryngeal Squamous Cell Carcinoma
- Ataxia
- Dysplasia
- Epilepsy
Interacting Proteins
- ADAM15
- ADAM9
- ATXN2
- DNM2
- EMD
- LRRK2
- PTPN23
- RAPH1
- SH3GL1
- SH3GL3
Pathways
- Endocytosis
- Clathrin-mediated Endocytosis
- Synaptic Vesicle Endocytosis
- Membrane Fission
- Transport
- Cell Cycle
- Localization
- Methylation
- Cell Death
- Pathogenesis
- Cell Motility
- Vesicle Uncoating
- Receptor Internalization
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SH3GL2
bosterbio.com/bosterbio-gene-info-cards/SH3GL2
References
PMID: 9169142 by Giachino C., et al. A novel SH3-containing human gene family preferentially expressed in the central nervous system.
PMID: 10531379 by Howard L., et al. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.