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- Table of Contents
SIRT4 Antibodies
AND SIRT4 ELISA kits, SIRT4 Proteins
Many biological assays use antibodies to detect SIRT4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIRT4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIRT4 antibodies...
Designing a Western blot for SIRT4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SIRT4 Western Blot GuideDesigning an IHC experiment for SIRT4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SIRT4 IHC GuideSIRT4 Infographic by Boster Bio
All SIRT4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03766-3
100 μg/vial
Cat # A03766-3
100 μg/vial
SIRT4 Overview
Facts about NAD-dependent protein lipoamidase sirtuin-4, mitochondrial.
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4)
Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and - biotinyl- than acetyl-lysine modifications.
Inhibits the pyruvate dehydrogenase complex (PDH) activity through the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | SIRT4 |
| Uniprot: | Q9Y6E7 |
| Entrez: | 23409 |
Family
| Belongs to: |
|---|
| sirtuin family |
Alternative Names
EC 2.4.2.-; EC 3.5.1; MGC130046; MGC130047; MGC57437; SIR2L4NAD-dependent ADP-ribosyltransferase sirtuin-4; sir2-like 4; SIR2-like protein 4; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 4; sirtuin 4; sirtuin type 4
Molecular Weight
Mass (kDA):
35.188 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.23-q24.31 |
| Sequence: | 12; NC_000012.12 (120290639..120313242) |
Tissue Specificity
Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus.
Subcellular Localizations
Mitochondrion matrix.
Diseases
- Malignant Neoplasms
- Diabetes Mellitus
- Trematode Infections
- Diabetes Mellitus, Non-insulin-dependent
- Metabolic Diseases
- Traditional Serrated Adenoma
- Neoplasms
- Fatty Liver
- Hyperinsulinism
- Inflammatory Response
- Obesity
- Diabetic Nephropathy
- Carcinoma
Interacting Proteins
- DLAT
- PDHX
- SLC25A5
Pathways
- Insulin Secretion
- Secretion
- Aging
- Localization
- Regulation Of Insulin Secretion
- Gene Silencing
- Inflammatory Response
- Protein Deacetylation
- Energy Homeostasis
- Senescence
- Drug Resistance
- Protein Acetylation
- Cell Death
PTMs
- Acetylation
- Ribosylation
- Deacetylation
Research Areas
- DNA Repair
- Epigenetics
- Homologous Recombination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIRT4
bosterbio.com/bosterbio-gene-info-cards/SIRT4
References
PMID: 10381378 by Frye R.A.; Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
PMID: 16959573 by Haigis M.C., et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
1 Publications of Boster SIRT4 Antibodies & ELISA Kits
- PubMed ID: -, Martin Maldonado,Jianying Chen,Huiqin Duan,Tianhua Huang,Gu Jiang,Ying Zhong,Hig...
*More publications can be found for each product on its corresponding product page