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- Table of Contents
Antileukoproteinase Antibodies
AND SLPI ELISA kits, Antileukoproteinase Proteins
Many biological assays use antibodies to detect Antileukoproteinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Antileukoproteinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Antileukoproteinase antibodies...
Designing a Western blot for Antileukoproteinase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLPI Western Blot GuideDesigning an IHC experiment for Antileukoproteinase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SLPI IHC GuideSLPI Infographic by Boster Bio
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SLPI Overview
Facts about Antileukoproteinase.
Antileukoproteinase (SLPI)
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.
major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SLPI |
| Uniprot: | P03973 |
| Entrez: | 6590 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ALK1; ALPProtease inhibitor WAP4; antileukoproteinase; BLPISeminal proteinase inhibitor; HUSI; HUSI-I; Mucus proteinase inhibitor; secretory leukocyte peptidase inhibitor; secretory leukocyte protease inhibitor (antileukoproteinase); Secretory leukocyte protease inhibitor; SLPI; WAP four-disulfide core domain protein 4; WAP4HUSI-1; WFDC4MPI
Molecular Weight
Mass (kDA):
14.326 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.12 |
| Sequence: | 20; NC_000020.11 (45252239..45254564, complement) |
Tissue Specificity
Detected in blood plasma (PubMed:24352879). Detected in bone marrow myeloid cells (PubMed:24352879). Detected in airway sputum (PubMed:2039600). Detected in parotid gland secretions (PubMed:3462719). Detected in seminal plasma (at protein level) (PubMed:3485543). Detected in uterus cervix (PubMed:3533531).
Subcellular Localizations
Secreted.
Diseases
- Inflammation
- Lung Diseases
- Malignant Neoplasms
- Neoplasms
- Hiv Infections
- Chronic Obstructive Airway Disease
- Carcinoma
- Fibrosis
- Immunologic Deficiency Syndromes
- Cystic Fibrosis
- Infective Disorder
- Lung Diseases, Obstructive
- Pulmonary Emphysema
Interacting Proteins
- FAM9B
- SGTA
Pathways
- Secretion
- Pathogenesis
- Immune Response
- Inflammatory Response
- Wound Healing
- Proteolysis
- Localization
- Innate Immune Response
- Phagocytosis
- Transport
- Cell Growth
- Cell Proliferation
- Coagulation
PTMs
- Cleavage
- Glycosylation
- Oxidation
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLPI
bosterbio.com/bosterbio-gene-info-cards/SLPI
References
PMID: 3533531 by Heinzel R., et al. Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus.
PMID: 3640338 by Stetler G., et al. Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases.