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- Table of Contents
Facts about Structural maintenance of chromosomes protein 3.
In anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair.
Human | |
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Gene Name: | SMC3 |
Uniprot: | Q9UQE7 |
Entrez: | 9126 |
Belongs to: |
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SMC family |
Bamacan; BAMSMC protein 3; Basement membrane-associated chondroitin proteoglycan; BMH; chondroitin sulfate proteoglycan 6 (bamacan); Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide; CSPG6structural maintenance of chromosomes protein 3; hCAP; HCAPbamacan; SMC-3; SMC3L1CDLS3; structural maintenance of chromosomes 3
Mass (kDA):
141.542 kDA
Human | |
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Location: | 10q25.2 |
Sequence: | 10; NC_000010.11 (110567695..110606048) |
Nucleus. Chromosome. Chromosome, centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity).
Antibodies that recognize SMC3 are extremely beneficial for the treatment of genes. Boster Bio's products have been tested across multiple platforms, using both positive and negative samples. Their antibodies are extremely specific and possess high affinity. The company also offers product credits to scientists who review their products for the first time. Scientists from all around the world are rewarded for their contribution. Continue reading to learn more about Boster Bio's SMC3 marker antibody.
Boster Bio produces high-affinity, primary antibodies against the marker SMC3 to improve research efficiency. These antibodies have been tested quantitatively on a panel comprising 250 tissue samples and exhibited high affinity. The antibodies are based on knowledge gained from the design of immunogens. They are backed with technical support offered by Sanbio, which is a BeNeLux distributor. The antibodies have been validated for Western Blotting and immunohistochemistry, and are suitable for both quantitative and qualitative applications.
In the latter part of the nineties, Steven Boster introduced his first product to the market, the "Picoband" ELISA kit. This platform allowed him to develop hundreds of principal antibodies for various applications including IHC. Boster was China's largest manufacturer of catalog antibodies by the late nineties. Boster also invented PicoKine(tm), a proprietary ELISA platform that utilizes proprietary trade secrets. These high-affinity ELISA kit is available in a variety of concentrations and sensitivity levels.
Applications for research are well served by high-affinity primate antibodies which utilize the marker SMC-3. These antibodies recognize and bind various antigens, including those found in bacteria. They are often used in immunoassays, including Western Blotting, immunohistochemistry, and histopathology. ELISA is also known as Enzyme Linked Immunosorbent Assay, is a method to determine how many cells are expressing a particular antigen.
The Anti-Bax Antibody is part of the Boster Bio Picoband (tm) catalog and can be used to conduct research on this protein. It reacts with Human and Mouse, Rat, and Monkey cells. The antibody is confirmed by Western blotting and Immunofluorescence. The Boster Quality Guarantee safeguards all products from quality flaws. The company is actively expanding its product range to ensure the best quality.
PMID: 9506951 by Shimizu K., et al. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.
PMID: 18614053 by Zhang J., et al. Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.