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- Table of Contents
SMYD2 Antibodies
AND SMYD2 ELISA kits, SMYD2 Proteins
Many biological assays use antibodies to detect SMYD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMYD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMYD2 antibodies...
Designing a Western blot for SMYD2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SMYD2 Western Blot GuideDesigning an IHC experiment for SMYD2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMYD2 IHC GuideSMYD2 Infographic by Boster Bio
All SMYD2 Products
Product
Figures
Specificity
Applications
Price
SMYD2 Overview
Facts about N-lysine methyltransferase SMYD2.
N-lysine methyltransferase SMYD2 (SMYD2)
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, such as p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2).
Shows even greater methyltransferase activity on p53/TP53. Monomethylates'Lys-370' of p53/TP53, resulting in diminished DNA-binding action and subsequent transcriptional regulation action of p53/TP53.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMYD2 |
| Uniprot: | Q9NRG4 |
| Entrez: | 56950 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
EC 2.1.1.43; Histone methyltransferase SMYD2; HSKM-Bzinc finger, MYND domain containing 14; KMT3CEC 2.1.1.-; Lysine N-methyltransferase 3C; MGC119305; SET and MYND domain containing 2; SET and MYND domain-containing protein 2; ZMYND14
Molecular Weight
Mass (kDA):
49.688 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.3 |
| Sequence: | 1; NC_000001.11 (214281159..214337136) |
Subcellular Localizations
Cytoplasm, cytosol. Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Esophageal Neoplasms
- Sclerosis
- Primary Lateral Sclerosis
- Dementia
- Hypoxia
- Amyotrophic Lateral Sclerosis
Interacting Proteins
- TP53
Pathways
- Methylation
- Cell Cycle
- Cell Proliferation
- Demethylation
- Heart Development
- Translational Initiation
- Response To Stress
- Dna Repair
- Neuron Death
- Senescence
- Protein Methylation
- Cell Division
- Dna Replication
PTMs
- Methylation
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMYD2
bosterbio.com/bosterbio-gene-info-cards/SMYD2
References
PMID: 17108971 by Huang J., et al. Repression of p53 activity by Smyd2-mediated methylation.
PMID: 17242690 by Wang C., et al. C/EBPalphap30 plays transcriptional regulatory roles distinct from C/EBPalphap42.