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- Table of Contents
Sphingosine kinase 1 Antibodies
AND SPHK1 ELISA kits, Sphingosine kinase 1 Proteins
Many biological assays use antibodies to detect Sphingosine kinase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sphingosine kinase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sphingosine kinase 1 antibodies...
Designing a Western blot for Sphingosine kinase 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPHK1 Western Blot GuideSPHK1 Infographic by Boster Bio
All SPHK1 Products
Product
Figures
Specificity
Applications
Price
Anti-SPHK1 Antibody Picoband®
3 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01390-1
100 μg/vial
Cat # A01390-1
100 μg/vial
Human
ELISA
$750
Cat # EK1501
96 wells/kit, with removable strips.
Cat # EK1501
96 wells/kit, with removable strips.
SPHK1 Overview
Facts about Sphingosine kinase 1.
Sphingosine kinase 1 (SPHK1)
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N- dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | SPHK1 |
| Uniprot: | Q9NYA1 |
| Entrez: | 8877 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 2.7.1.91; SK1; sphingosine kinase 1; SPHK1; SPHKSK 1; SPK 1; SPK; SPK1
Molecular Weight
Mass (kDA):
42.518 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.1 |
| Sequence: | 17; NC_000017.11 (76383204..76387855) |
Tissue Specificity
Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Cell membrane. Endosome membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Cell junction, synapse. Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831). Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Tumor Angiogenesis
- Carcinoma
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Cell Invasion
- Fibrosis
- Malignant Neoplasm Of Prostate
- Mammary Neoplasms
Interacting Proteins
- CTSB
- EEF1A1
- FHL2
- SPHKAP
- TRAF6
Pathways
- Cell Proliferation
- Cell Growth
- Cell Death
- Angiogenesis
- Secretion
- Cell Migration
- Rna Interference
- Pathogenesis
- Localization
- Cell Cycle
- Cytokine Production
- Cell Motility
- Chemotaxis
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPHK1
bosterbio.com/bosterbio-gene-info-cards/SPHK1
References
PMID: 10863092 by Melendez A.J., et al. Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution.
PMID: 10802064 by Nava V.E., et al. Functional characterization of human sphingosine kinase-1.
1 Publications of Boster Sphingosine kinase 1 Antibodies & ELISA Kits
- PubMed ID: 29108256, Chen C, Gong W, Li C, Xiong F, Wang S, Huang J, Wang Y, Chen Z, Chen Q, Liu P, L...
*More publications can be found for each product on its corresponding product page