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- Table of Contents
SPTLC1 Antibodies
AND SPTLC1 ELISA kits, SPTLC1 Proteins
Many biological assays use antibodies to detect SPTLC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTLC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTLC1 antibodies...
Designing a Western blot for SPTLC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPTLC1 Western Blot GuideDesigning an IHC experiment for SPTLC1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SPTLC1 IHC GuideSPTLC1 Infographic by Boster Bio
All SPTLC1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9894
100 μg/vial
Cat # PB9894
100 μg/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1777
100 μg/vial
Cat # PA1777
100 μg/vial
SPTLC1 Overview
Facts about Serine palmitoyltransferase 1.
Serine palmitoyltransferase 1 (SPTLC1)
Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 represents the catalytic core.
The composition of this serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex indicates a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme utilizes both C14-CoA and C16-CoA as substrates, with a small preference for C14-CoA.
Gene Information
| Human | |
|---|---|
| Gene Name: | SPTLC1 |
| Uniprot: | O15269 |
| Entrez: | 10558 |
Family
| Belongs to: |
|---|
| class-II pyridoxal-phosphate-dependent aminotransferase family |
Alternative Names
EC 2.3.1.50; hereditary sensory neuropathy, type 1; HSAN1; LBC1; LCB 1; LCB1HSAN; Long chain base biosynthesis protein 1; MGC14645; serine C-palmitoyltransferase; serine palmitoyltransferase 1; serine palmitoyltransferase, long chain base subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1HSN1; SPTI
Molecular Weight
Mass (kDA):
52.744 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q22.31 |
| Sequence: | 9; NC_000009.12 (92031141..92115413, complement) |
Tissue Specificity
Widely expressed. Not detected in small intestine.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass membrane protein.
Diseases
- Hereditary Sensory And Autonomic Neuropathies
- Sensory Neuropathy
- Sensory Neuropathy, Hereditary
- Hereditary Sensory Autonomic Neuropathy, Type 1
- Absence Of Sensation
- Peripheral Neuropathy
- Pain
- Ulcer
- Weakness
- Nervousness
- Inherited Neuropathy
Interacting Proteins
- ORMDL3
- SPTLC3
Pathways
- Localization
- Pathogenesis
- Transport
- Cell Migration
- Cell Proliferation
- Cell Death
- Neural Tube Closure
- Glycosylation
- Hypersensitivity
- Reflex
- Tube Closure
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTLC1
bosterbio.com/bosterbio-gene-info-cards/SPTLC1
References
PMID: 9363775 by Weiss B., et al. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis.
PMID: 11242114 by Dawkins J.L., et al. Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I.