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- Table of Contents
STUB1 Antibodies
AND STUB1 ELISA kits, STUB1 Proteins
Many biological assays use antibodies to detect STUB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STUB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STUB1 antibodies...
Designing a Western blot for STUB1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the STUB1 Western Blot GuideSTUB1 Infographic by Boster Bio
All STUB1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M01236
100 μg/vial
Cat # M01236
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01236-1
100 μg/vial
Cat # A01236-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M01236-2
100 μl/vial
Cat # M01236-2
100 μl/vial
STUB1 Overview
Facts about E3 ubiquitin-protein ligase CHIP.
E3 ubiquitin-protein ligase CHIP (STUB1)
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension.
Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of many chaperone complexes, including Hsp70, Hsc70 and Hsp90.
Gene Information
| Human | |
|---|---|
| Gene Name: | STUB1 |
| Uniprot: | Q9UNE7 |
| Entrez: | 10273 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Antigen NY-CO-7; Carboxy terminus of Hsp70-interacting protein; CHIP; CHIPSTIP1 homology and U box-containing protein 1; CLL-associated antigen KW-8; E3 ubiquitin-protein ligase CHIP; EC 6.3.2.-; heat shock protein A binding protein 2 (c-terminal); HSPABP2; NY-CO-7; SDCCAG7; serologically defined colon cancer antigen 7; STIP1 homology and U-box containing protein 1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; STUB1; UBOX1
Molecular Weight
Mass (kDA):
34.856 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (680410..682801) |
Tissue Specificity
Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highly expressed in skeletal muscle, heart, pancreas, brain and placenta (PubMed:10330192, PubMed:11435423). Detected in kidney, liver and lung (PubMed:10330192, PubMed:11435423).
Subcellular Localizations
Cytoplasm. Nucleus. Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg).
Diseases
- Malignant Neoplasms
- Neoplasms
- Neurodegenerative Disorders
- Alzheimer's Disease
- Parkinson Disease
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cystic Fibrosis
- Fibrosis
- Nerve Degeneration
- Leukemia
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- ACD
- AKT1
- ATCAY
- BAG1
- BAG2
- BAG3
- CCL28
- EGFR
- FOXP3
- HSP90AA1
Pathways
- Protein Folding
- Cell Death
- Pathogenesis
- Proteolysis
- Cell Growth
- Rna Interference
- Localization
- Transport
- Translation
- Autophagy
- Cell Proliferation
- Conjugation
- Osteoblast Differentiation
PTMs
- Ubiquitination
- Phosphorylation
- Hydroxylation
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STUB1
bosterbio.com/bosterbio-gene-info-cards/STUB1
References
PMID: 9610721 by Scanlan M.J., et al. Characterization of human colon cancer antigens recognized by autologous antibodies.
PMID: 10330192 by Ballinger C.A., et al. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.