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- Table of Contents
SNRPD3 Antibodies
AND SNRPD3 ELISA kits, SNRPD3 Proteins
Many biological assays use antibodies to detect SNRPD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SNRPD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SNRPD3 antibodies...
Designing an IHC experiment for SNRPD3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SNRPD3 IHC GuideSNRPD3 Infographic by Boster Bio
All SNRPD3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, WB
$370
Cat # A09533-1
100 μg/vial
Cat # A09533-1
100 μg/vial
SNRPD3 Overview
Facts about Small nuclear ribonucleoprotein Sm D3.
Small nuclear ribonucleoprotein Sm D3 (SNRPD3)
Plays role in pre-mRNA splicing as core component of this SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of the pre- catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Is also a component of the minor U12 spliceosome (PubMed:15146077). Included in the U7 snRNP it's involved in histone pre-mRNA 3'-end processing (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SNRPD3 |
| Uniprot: | P62318 |
| Entrez: | 6634 |
Family
| Belongs to: |
|---|
| snRNP core protein family |
Alternative Names
small nuclear ribonucleoprotein D3 polypeptide 18kDa; small nuclear ribonucleoprotein Sm D3; snRNP core protein D3
Molecular Weight
Mass (kDA):
13.916 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q11.23 |
| Sequence: | 22; NC_000022.11 (24555650..24574971) |
Subcellular Localizations
Cytoplasm, cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Diseases
- Lupus Erythematosus, Systemic
- Muscular Atrophy
- Atrophy
- Spinal Muscular Atrophy
- Mixed Connective Tissue Disease
- Autoimmune Diseases
- Connective Tissue Diseases
- Autoimmune Reaction
- Neoplasms
- Epstein-barr Virus Infections
- Infectious Mononucleosis
- Neurodegenerative Disorders
Interacting Proteins
- CLNS1A
- ERH
- LSM7
- SNRPB
Pathways
- Methylation
- Localization
- Protein Methylation
- Cell Proliferation
- Mrna Splicing
- Cell Cycle
- Mitosis
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNRPD3
bosterbio.com/bosterbio-gene-info-cards/SNRPD3
References
PMID: 7527560 by Lehmeier T., et al. cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction.
PMID: 11747828 by Meister G., et al. Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.