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- Table of Contents
Facts about Transcription factor 7.
Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.
Human | |
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Gene Name: | TCF7 |
Uniprot: | P36402 |
Entrez: | 6932 |
Belongs to: |
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TCF/LEF family |
FLJ36364; MGC47735; T-cell factor 1; T-cell specific; TCF1; TCF7; TCF-7; transcription factor 7 (T-cell specific, HMG-box)
Mass (kDA):
41.642 kDA
Human | |
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Location: | 5q31.1 |
Sequence: | 5; NC_000005.10 (134114681..134148229) |
Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
Nucleus.
PMID: 1989880 by van de Wetering M., et al. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.
PMID: 1569101 by van de Wetering M., et al. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
*More publications can be found for each product on its corresponding product page