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- Table of Contents
Transcription factor 7 Antibodies
AND TCF7 ELISA kits, Transcription factor 7 Proteins
Many biological assays use antibodies to detect Transcription factor 7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor 7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor 7 antibodies...
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TCF7 Infographic by Boster Bio
All TCF7 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01315-1
20μL, 40μL, 100μL, 200μL
Cat # M01315-1
20μL, 40μL, 100μL, 200μL
TCF7 Overview
Facts about Transcription factor 7.
Transcription factor 7 (TCF7)
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes.
Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.
Gene Information
| Human | |
|---|---|
| Gene Name: | TCF7 |
| Uniprot: | P36402 |
| Entrez: | 6932 |
Family
| Belongs to: |
|---|
| TCF/LEF family |
Alternative Names
FLJ36364; MGC47735; T-cell factor 1; T-cell specific; TCF1; TCF7; TCF-7; transcription factor 7 (T-cell specific, HMG-box)
Molecular Weight
Mass (kDA):
41.642 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.1 |
| Sequence: | 5; NC_000005.10 (134114681..134148229) |
Tissue Specificity
Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Malignant Tumor Of Colon
- Diabetes Mellitus
- Autoimmunity
- Diabetes Mellitus, Insulin-dependent
- Colonic Neoplasms
- Lymphoma
- Malignant Paraganglionic Neoplasm
- Colorectal Cancer
- Tissue Adhesions
Interacting Proteins
- CTNNB1
- MLLT11
Pathways
- Cell Development
- Cell Differentiation
- T Cell Differentiation
- Localization
- Cell Proliferation
- Pathogenesis
- Cell Cycle
- Osteoblast Differentiation
- Cell Growth
- Cell Maturation
- Cell Adhesion
- Cell Activation
- T Cell Activation
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCF7
bosterbio.com/bosterbio-gene-info-cards/TCF7
References
PMID: 1989880 by van de Wetering M., et al. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.
PMID: 1569101 by van de Wetering M., et al. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
1 Publications of Boster Transcription factor 7 Antibodies & ELISA Kits
- PubMed ID: 10.1038/s41420-021-00775-8, LncRNA4930473A02Rik promotes cardiac hypertrophy by regulating TCF7 via sponging...
*More publications can be found for each product on its corresponding product page