Teashirt homolog 3 Antibodies

AND TSHZ3 ELISA kits, Teashirt homolog 3 Proteins

Many biological assays use antibodies to detect Teashirt homolog 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Teashirt homolog 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Teashirt homolog 3 antibodies...

We validate the specificity of these antibodies to Teashirt homolog 3 by testing them on tissues known to express TSHZ3 positively and negatively. Browse below to find the TSHZ3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Teashirt homolog 3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the TSHZ3 IHC Guide

TSHZ3 Infographic by Boster Bio

All TSHZ3 Products

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Anti-Teashirt homolog 3 TSHZ3 Antibody

Western blot analysis of TSHZ3 in mouse brain tissue lysate with TSHZ3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

Immunohistochemistry of TSHZ3 in mouse brain tissue with TSHZ3 antibody at 2

Immunofluorescence of TSHZ3 in mouse brain tissue with TSHZ3 antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A08453
0.1 mg

ZNF537 (TSHZ3) (NM_020856) Human Recombinant Protein

Coomassie blue staining of purified TSHZ3 protein

$1249
Cat # PROTQ63HK5
20 µg

TSHZ3 Overview

Facts about Teashirt homolog 3.

TSHZ3 3D structure. Source: alphafold

Teashirt homolog 3 (TSHZ3)

Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression requires the recruitment of histone deacetylases HDAC1 and HDAC2.

Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow management.

Gene Information

Human
Gene Name:	TSHZ3
Uniprot:	Q63HK5
Entrez:	57616

Family

Belongs to:

teashirt C2H2-type zinc-finger protein family

Alternative Names

FLJ54422; KIAA1474; teashirt 3; teashirt zinc finger homeobox 3; zinc finger protein 537; ZNF537

Molecular Weight

Mass (kDA):
118.566 kDA

Genomic Context


Human

Location:	19q12
Sequence:	19; NC_000019.10 (31149876..31349436, complement)

Tissue Specificity

Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease (PubMed:18776146, PubMed:19343227). Expressed in the fetal neocortex (PubMed:27668656).

Subcellular Localizations

Nucleus. Cell projection, growth cone. Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus.

Diseases

Hydronephrosis
Malignant Neoplasm Of Breast
Multicystic Renal Dysplasia, Bilateral
Malignant Neoplasms
Mammary Neoplasms
Congenital Hydronephrosis
Ureteral Obstruction
Malignant Neoplasm Of Prostate
Obstruction Of Pelviureteric Junction
Carcinogenesis
Neoplasms
Nervousness

Dental Plaque
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Adenocarcinoma, Clear Cell
Noma
Germline Mutation Abnormality
Chromosomal Duplication

Interacting Proteins

CCDC155
CEP63
CEP70
KRT40
MAD1L1

MTUS2
SPAG5
TAX1BP1
TFIP11
TRAF2

TRIM23
TRIM27
TRIM54

Pathways

Peristalsis
Methylation
Regeneration
Smooth Muscle Contraction
Muscle Cell Differentiation
Cell Death
Cell Cycle
Cell Differentiation
Muscle Contraction

Eye Development
Smooth Muscle Cell Differentiation
Tendon Development

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSHZ3

References

PMID: 18776146 by Caubit X., et al. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.

PMID: 19343227 by Kajiwara Y., et al. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.