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Binds to FN14 and possibly also to TNRFSF12/APO3.Weak inducer of apoptosis in certain cell types.
Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells.
|tumor necrosis factor family|
|Sequence:||17; NC_000017.11 (7549058..7557881)|
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted.; [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein.