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- Table of Contents
TNFSF12 Antibodies
AND TNFSF12 ELISA kits, TNFSF12 Proteins
Many biological assays use antibodies to detect TNFSF12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNFSF12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNFSF12 antibodies...
Designing a Western blot for TNFSF12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TNFSF12 Western Blot GuideDesigning an IHC experiment for TNFSF12? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TNFSF12 IHC GuideTNFSF12 Infographic by Boster Bio
All TNFSF12 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0920
96 wells/kit, with removable strips.
Cat # EK0920
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1176
96 wells/kit, with removable strips.
Cat # EK1176
96 wells/kit, with removable strips.
Rat
ELISA
$499
Cat # EK1177
96 wells/kit, with removable strips.
Cat # EK1177
96 wells/kit, with removable strips.
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02009-1
100 μg
Cat # M02009-1
100 μg
Mouse
Cell Culture
$77
Cat # PROTO54907
5ug,20ug,100ug
Cat # PROTO54907
5ug,20ug,100ug
Human
Cell Culture
$77
Cat # PROTO43508-2
5ug,20ug,100ug
Cat # PROTO43508-2
5ug,20ug,100ug
TNFSF12 Overview
Facts about Tumor necrosis factor ligand superfamily member 12.
Tumor necrosis factor ligand superfamily member 12 (TNFSF12)
Binds to FN14 and possibly also to TNRFSF12/APO3.
Weak inducer of apoptosis in certain cell types.Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | TNFSF12 |
| Uniprot: | O43508 |
| Entrez: | 8742 |
Family
| Belongs to: |
|---|
| tumor necrosis factor family |
Alternative Names
APO3 ligand; APO3LMGC20669; DR3LGTWEAKAPO3/DR3 ligand; MGC129581; TNF-related weak inducer of apoptosis; TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand superfamily member 12; TWEAK
Molecular Weight
Mass (kDA):
27.216 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7549058..7557881) |
Tissue Specificity
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted.; [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein.
Diseases
- Inflammation
- Tumor Angiogenesis
- Malignant Neoplasms
- Neoplasms
- Lupus Erythematosus, Systemic
- Kidney Diseases
- Atherosclerosis
- Nephritis
- Rheumatoid Arthritis
- Lupus Nephritis
- Arthritis
- Pathologic Neovascularization
- Autoimmune Reaction
Interacting Proteins
- DICER1
- TNFRSF12A
Pathways
- Pathogenesis
- Angiogenesis
- Cell Death
- Cell Proliferation
- Secretion
- Cell Growth
- Inflammatory Response
- Regeneration
- Muscle Atrophy
- Cytokine Production
- Tissue Remodeling
- Skeletal Muscle Atrophy
- Cell Migration
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Angiogenesis
- Apoptosis
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFSF12
bosterbio.com/bosterbio-gene-info-cards/TNFSF12
References
PMID: 9405449 by Chicheportiche Y., et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.
PMID: 9560343 by Marsters S.A., et al. Identification of a ligand for the death-domain-containing receptor Apo3.
1 Publications of Boster TNFSF12 Antibodies & ELISA Kits
- PubMed ID: 10.1177/0960327119845038, How much apoptosis does carbon monoxide poisoning cause? Primary clinical solubl...
*More publications can be found for each product on its corresponding product page