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Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA.TNFSF13/APRIL binds to the exact same 2 receptors.
Collectively, they form a two ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of older B-cells and the B-cell response.
|tumor necrosis factor family|
|Sequence:||13; NC_000013.11 (108268240..108308484)|
Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines.
Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.
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