Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA.

TNFSF13/APRIL binds to the exact same 2 receptors.

Collectively, they form a two ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of older B-cells and the B-cell response.