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TNFSF14 Antibodies
AND TNFSF14 ELISA kits, TNFSF14 Proteins
Many biological assays use antibodies to detect TNFSF14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNFSF14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNFSF14 antibodies...
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TNFSF14 Infographic by Boster Bio
All TNFSF14 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0990
96 wells/kit, with removable strips.
Cat # EK0990
96 wells/kit, with removable strips.
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A03516-2
100 μg/vial
Cat # A03516-2
100 μg/vial
TNFSF14 Overview
Facts about Tumor necrosis factor ligand superfamily member 14.
Tumor necrosis factor ligand superfamily member 14 (TNFSF14)
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its consequences.
Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Gene Information
| Human | |
|---|---|
| Gene Name: | TNFSF14 |
| Uniprot: | O43557 |
| Entrez: | 8740 |
Family
| Belongs to: |
|---|
| tumor necrosis factor family |
Alternative Names
CD258 antigen; CD258; delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator ligand; HVEM-L; HVEMLherpesvirus entry mediator-ligand; ligand for herpesvirus entry mediator; LIGHT; LIGHTherpesvirus entry mediator A; LTg; TNFSF14; TR2; tumor necrosis factor (ligand) superfamily, member 14; tumor necrosis factor ligand superfamily member 14; tumor necrosis factor receptor-like 2; tumor necrosis factor superfamily member LIGHT
Molecular Weight
Mass (kDA):
26.35 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (6658126..6670595, complement) |
Tissue Specificity
Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
Subcellular Localizations
[Tumor necrosis factor ligand superfamily member 14, membrane form]: Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted.; [Isoform 2]: Cytoplasm.
Diseases
- Inflammation
- Neoplasms
- Malignant Neoplasms
- Autoimmune Reaction
- Autoimmune Diseases
- Arthritis
- Tissue Adhesions
- Carcinoma
- Rheumatoid Arthritis
- Autoimmunity
- Infective Disorder
Interacting Proteins
- LTBR
- Ltbr
- TNFRSF14
- TNFRSF6B
Pathways
- Pathogenesis
- Cell Proliferation
- Secretion
- Cell Activation
- T Cell Activation
- Immune Response
- T Cell Proliferation
- Cell Death
- Cytokine Production
- Cell Differentiation
- Cell Maturation
- T Cell Homeostasis
- Cytokine Secretion
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFSF14
bosterbio.com/bosterbio-gene-info-cards/TNFSF14
References
PMID: 9462508 by Mauri D.N., et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.
PMID: 9765287 by Harrop J.A., et al. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth.