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- Table of Contents
TNIK Antibodies
AND TNIK ELISA kits, TNIK Proteins
Many biological assays use antibodies to detect TNIK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNIK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNIK antibodies...
Designing a Western blot for TNIK? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TNIK Western Blot GuideDesigning an IHC experiment for TNIK? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TNIK IHC GuideTNIK Infographic by Boster Bio
All TNIK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03934-3
100 µg/vial
Cat # A03934-3
100 µg/vial
TNIK Overview
Facts about TRAF2 and NCK-interacting protein kinase.
TRAF2 and NCK-interacting protein kinase (TNIK)
Serine/threonine kinase that serves as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression.
Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress.
Gene Information
| Human | |
|---|---|
| Gene Name: | TNIK |
| Uniprot: | Q9UKE5 |
| Entrez: | 23043 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; KIAA0551EC 2.7.11.1; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase
Molecular Weight
Mass (kDA):
154.943 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.2-q26.31 |
| Sequence: | 3; NC_000003.12 (171058414..171460408, complement) |
Tissue Specificity
Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
Subcellular Localizations
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Diseases
- Malignant Neoplasms
- Schizophrenia
- Colorectal Cancer
- Mental Disorders
- Bipolar Disorder
- Tissue Adhesions
- Colorectal Neoplasms
- Malignant Tumor Of Colon
- Neoplasms
- Anxiety Disorders
- Autistic Disorder
- Malnutrition
- Malignant Neoplasm Of Breast
Interacting Proteins
- CTNNB1
- DISC1
- IKBKB
- MAP3K7
- TAB2
- Tanc1
- TCF7L2
- TRAF2
- TRAF6
Pathways
- Cell Adhesion
- Localization
- Brain Development
- Transport
- Cell Proliferation
- Response To Stress
- Convergent Extension
- Camp-mediated Signaling
- Regulation Of Cytoskeleton
- Immune Response
- Synaptic Transmission
- Endosome Localization
PTMs
- Phosphorylation
- Farnesylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNIK
bosterbio.com/bosterbio-gene-info-cards/TNIK
References
PMID: 10521462 by Fu C.A., et al. TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton.
PMID: 15342639 by Taira K., et al. The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.