UBA6 Antibodies

AND UBA6 ELISA kits, UBA6 Proteins

Many biological assays use antibodies to detect UBA6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBA6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBA6 antibodies...

We validate the specificity of these antibodies to UBA6 by testing them on tissues known to express UBA6 positively and negatively. Browse below to find the UBA6 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for UBA6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the UBA6 IHC Guide

UBA6 Infographic by Boster Bio

All UBA6 Products

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Product

Figures

Specificity

Applications

Price

Anti-UBA6 Antibody Picoband®

Western blot analysis of UBA6 using anti-UBA6 antibody (A03213-2)

IHC analysis of UBA6 using anti-UBA6 antibody (A03213-2)

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A03213-2
100 μg/vial

UBA6 (NM_018227) Human Over-expression Lysate

Human

$628
Cat # LS055236
20 µg, 100 µg

UBA6 (NM_018227) Human Recombinant Protein

Coomassie blue staining of purified UBA6 protein

$1249
Cat # PROTA0AVT1
20 µg

Human Use1/UBE2Z Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9H832
Starting from 10ug

UBA6 Overview

Facts about Ubiquitin-like modifier-activating enzyme 6.

UBA6 3D structure. Source: alphafold

Ubiquitin-like modifier-activating enzyme 6 (UBA6)

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Particular for ubiquitin, doesn't activate ubiquitin-like peptides.

Differs from UBE1 in its specificity for substrate E2 charging. Doesn't bill cell cycle E2s, such as CDC34.

Gene Information

Human
Gene Name:	UBA6
Uniprot:	A0AVT1
Entrez:	55236

Family

Belongs to:

ubiquitin-activating E1 family

Alternative Names

E1-L2; FLJ10808; FLJ23367; Monocyte protein 4; MOP4; MOP-4; UBA6, ubiquitin-activating enzyme E1; UBE1L2; Ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1-like 2; Ubiquitin-activating enzyme E1-like protein 2; ubiquitin-like modifier activating enzyme 6; ubiquitin-like modifier-activating enzyme 6

Molecular Weight

Mass (kDA):
117.97 kDA

Genomic Context


Human

Location:	4q13.2
Sequence:	4; NC_000004.12 (67612652..67701155, complement)

Tissue Specificity

Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.

Diseases

Malignant Neoplasms
Amaurosis
Leber Congenital Amaurosis
Ataxia Telangiectasia
Blind Vision

Interacting Proteins

HMBOX1

Pathways

Conjugation
Pathogenesis
Cell Cycle
Sister Chromatid Cohesion
Mitosis
Cell Differentiation
Meiosis

Oogenesis
Autophagy

PTMs

Carboxylation

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBA6

References

PMID: 15202508 by Zhu H., et al. Identification and characteristics of a novel E1 like gene nUBE1L in human testis.

PMID: 17597759 by Jin J., et al. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.