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- Table of Contents
UBE2N Antibodies
AND UBE2N ELISA kits, UBE2N Proteins
Many biological assays use antibodies to detect UBE2N, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBE2N in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBE2N antibodies...
Designing an IHC experiment for UBE2N? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the UBE2N IHC GuideUBE2N Infographic by Boster Bio
All UBE2N Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02462-2
100 μg/vial
Cat # A02462-2
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02462-1
100 μl/vial
Cat # M02462-1
100 μl/vial
UBE2N Overview
Facts about Ubiquitin-conjugating enzyme E2 N.
Ubiquitin-conjugating enzyme E2 N (UBE2N)
This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes.
Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway also contributes to the survival of cells after DNA damage.
Gene Information
| Human | |
|---|---|
| Gene Name: | UBE2N |
| Uniprot: | P61088 |
| Entrez: | 7334 |
Family
| Belongs to: |
|---|
| ubiquitin-conjugating enzyme family |
Alternative Names
bendless-like ubiquitin conjugating enzyme; Bendless-like ubiquitin-conjugating enzyme; BLU; EC 6.3.2.19; MGC131857; MGC8489; UBC13; UbcH13; UbcH-ben; UBE2N; Ubiquitin carrier protein N; ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Ubiquitin-protein ligase N; yeast UBC13 homolog
Molecular Weight
Mass (kDA):
17.138 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q22 |
| Sequence: | 12; NC_000012.12 (93405684..93442336, complement) |
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Ataxia
- Genomic Instability
- Ataxia Telangiectasia
- Carcinoma
- Immunologic Deficiency Syndromes
- Lymphoma
- Genotoxic Stress
- Lymphoma, Non-hodgkin
- Malignant Neoplasm Of Lung
- Lung Neoplasms
Interacting Proteins
- BIRC3
- HLTF
- LRSAM1
- Map3k1
- RBCK1
- RFWD3
- RNF11
- RNF13
- RNF168
- RNF182
Pathways
- Dna Repair
- Conjugation
- Translesion Synthesis
- Postreplication Repair
- Localization
- Dna Replication
- Osteoclast Differentiation
- Hypersensitivity
- Mitosis
- Cell Death
- Transport
- Histone Ubiquitination
- Regulation Of Signaling
PTMs
- Ubiquitination
- Phosphorylation
- Sumoylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBE2N
bosterbio.com/bosterbio-gene-info-cards/UBE2N
References
PMID: 8902611 by Yamaguchi T., et al. Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product.
PMID: 16122702 by Zou W., et al. ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin.