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- Table of Contents
Ubiquilin-4 Antibodies
AND UBQLN4 ELISA kits, Ubiquilin-4 Proteins
Many biological assays use antibodies to detect Ubiquilin-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ubiquilin-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ubiquilin-4 antibodies...
Designing an IHC experiment for Ubiquilin-4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the UBQLN4 IHC GuideUBQLN4 Infographic by Boster Bio
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UBQLN4 Overview
Facts about Ubiquilin-4.
Ubiquilin-4 (UBQLN4)
Plays a role in the regulation of protein degradation through the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (through UBA domain) to their polyubiquitin chains and by interacting (through ubiquitin-like domain) with the subunits of the proteasome (Ref.
6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | UBQLN4 |
| Uniprot: | Q9NRR5 |
| Entrez: | 56893 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
A1Uataxin-1 ubiquitin-like interacting protein; Ataxin-1 ubiquitin-like-interacting protein A1U; C1orf6ubiquilin-4; chromosome 1 open reading frame 6; UBINCIP75; ubiquilin 4
Molecular Weight
Mass (kDA):
63.853 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q22 |
| Sequence: | 1; NC_000001.11 (156033129..156053798, complement) |
Tissue Specificity
Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome. Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365). Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234). In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738).
Diseases
- Chikungunya Virus Infection
- Ataxia
- Mumps
- Alphavirus Infections
- Ataxia, Spinocerebellar
- Opca, Menzel Type
Interacting Proteins
- ATXN1
- FKBP2
- Gja1
- MAP1LC3A
- MLLT6
- PDLIM7
- RAI2
- TRIM32
- UBQLN1
- ZNF205
Pathways
- Gene Silencing
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBQLN4
bosterbio.com/bosterbio-gene-info-cards/UBQLN4
References
PMID: 11001934 by Davidson J.D., et al. Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein.
PMID: 10575211 by Fogli A., et al. Identification of two paralogous regions mapping to the short and long arms of human chromosome 2 comprising LIS1 pseudogenes.