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- Table of Contents
UBR2 Antibodies
AND UBR2 ELISA kits, UBR2 Proteins
Many biological assays use antibodies to detect UBR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBR2 antibodies...
Designing an IHC experiment for UBR2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the UBR2 IHC GuideUBR2 Infographic by Boster Bio
All UBR2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05812-2
100 μg/vial
Cat # A05812-2
100 μg/vial
UBR2 Overview
Facts about E3 ubiquitin-protein ligase UBR2.
E3 ubiquitin-protein ligase UBR2 (UBR2)
E3 ubiquitin-protein ligase that is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues which are destabilizing in line with the N-end rule, resulting in their ubiquitination and subsequent degradation.
Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis through ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Gene Information
| Human | |
|---|---|
| Gene Name: | UBR2 |
| Uniprot: | Q8IWV8 |
| Entrez: | 23304 |
Family
| Belongs to: |
|---|
| UBR1 family |
Alternative Names
bA49A4.1; C6orf133MGC71112; chromosome 6 open reading frame 133; dJ242G1.1; dJ392M17.3; DKFZp686C08114; E3 ubiquitin-protein ligase UBR2; EC 6.3.2.-; KIAA0349FLJ36357; N-recognin-2; RP3-392M17.3; ubiquitin protein ligase E3 component n-recognin 2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II
Molecular Weight
Mass (kDA):
200.538 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (42563954..42693505) |
Tissue Specificity
Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Subcellular Localizations
Nucleus. Associated with chromatin during meiosis.
Diseases
- Infertility
- Malignant Neoplasms
- Johanson-blizzard Syndrome
- Neurodegenerative Disorders
- Instabilities, Chromosomal
- Sclerosis
- Exocrine Pancreatic Insufficiency
- Primary Lateral Sclerosis
- Malignant Neoplasm Of Breast
- Anosmia
- Hypoxia
- Amyotrophic Lateral Sclerosis
- Immunologic Deficiency Syndromes
Pathways
- Meiosis
- Pachytene
- Spermatogenesis
- Proteolysis
- Prophase
- Hypersensitivity
- Male Meiosis
- S Phase
- Pathogenesis
- Histone Ubiquitination
- Aging
- Neurogenesis
- Histone Modification
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBR2
bosterbio.com/bosterbio-gene-info-cards/UBR2
References
PMID: 15548684 by Kwak K.S., et al. Regulation of protein catabolism by muscle-specific and cytokine- inducible ubiquitin ligase E3alpha-II during cancer cachexia.
PMID: 15317757 by Yin J., et al. RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.