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- Table of Contents
USP10 Antibodies
AND USP10 ELISA kits, USP10 Proteins
Many biological assays use antibodies to detect USP10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP10 antibodies...
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USP10 Infographic by Boster Bio
All USP10 Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M03786-1
100 µl
Cat # M03786-1
100 µl
USP10 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 10.
Ubiquitin carboxyl-terminal hydrolase 10 (USP10)
Hydrolase that may remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 activity and stabilize p53/TP53.
Following DNA damage, translocates into the nucleus and deubiquitinates p53/TP53, leading to modulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop which controls autophagy and p53/TP53 amounts: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP10 |
| Uniprot: | Q14694 |
| Entrez: | 9100 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 10; EC 3.4.19.12; KIAA0190MGC2621; ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific peptidase 10; ubiquitin specific protease 10; ubiquitin thioesterase 10; Ubiquitin Thiolesterase 10; Ubiquitin-specific-processing protease 10; UBPO; Uchrp; USP10
Molecular Weight
Mass (kDA):
87.134 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q24.1 |
| Sequence: | 16; NC_000016.10 (84699977..84779922) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm. Nucleus. Early endosome. Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447).
Diseases
- Neoplasms
- Malignant Neoplasms
- Cystic Fibrosis
- Fibrosis
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Liver Carcinoma
- Liver Neoplasms
- Stomach Neoplasms
- Microphthalmos
- Non-neoplastic Disorder
Interacting Proteins
- G3BP1
- G3BP2
- ZC3H12A
Pathways
- Secretion
- Transport
- Translation
- Localization
- Cellular Homeostasis
- Endocytic Recycling
- Cell Growth
- Golgi Localization
- Interaction With Host
- Stress Granule Assembly
- Nuclear Export
- Sensitization
- Cellular Response To Stress
PTMs
- Ubiquitination
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP10
bosterbio.com/bosterbio-gene-info-cards/USP10
References
PMID: 11439350 by Soncini C., et al. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.
PMID: 17693683 by Tang L.-Y., et al. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.