Transitional endoplasmic reticulum ATPase (VCP)

Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes in the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER).

Vesicle budding from the tER is an ATP-dependent procedure. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is essential for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.