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- Table of Contents
VCP Antibodies
AND VCP ELISA kits, VCP Proteins
Many biological assays use antibodies to detect VCP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VCP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VCP antibodies...
Designing a Western blot for VCP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the VCP Western Blot GuideDesigning an IHC experiment for VCP? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the VCP IHC GuideVCP Infographic by Boster Bio
All VCP Products
Product
Figures
Specificity
Applications
Price
Anti-VCP Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9454
100 μg/vial
Cat # PB9454
100 μg/vial
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PA2137
100 μg/vial
Cat # PA2137
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00610
100 μl
Cat # M00610
100 μl
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00610-2
100 μg/vial
Cat # A00610-2
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2630
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2630
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1592
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1592
1 kit, containing one 96-well plate and all necessary reagents
VCP Overview
Facts about Transitional endoplasmic reticulum ATPase.
Transitional endoplasmic reticulum ATPase (VCP)
Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes in the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER).
Vesicle budding from the tER is an ATP-dependent procedure. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is essential for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
Gene Information
| Human | |
|---|---|
| Gene Name: | VCP |
| Uniprot: | P55072 |
| Entrez: | 7415 |
Family
| Belongs to: |
|---|
| AAA ATPase family |
Alternative Names
15S Mg(2+)-ATPase p97 subunit; IBMPFD; IBMPFDMGC8560; MGC131997; p97; TER ATPase; TERA; transitional endoplasmic reticulum ATPase; valosin containing protein; Valosin-containing proteinMGC148092; VCP; yeast Cdc48p homolog
Molecular Weight
Mass (kDA):
89.322 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.3 |
| Sequence: | 9; NC_000009.12 (35056064..35072668, complement) |
Subcellular Localizations
Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Cytoplasm, Stress granule. Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787). Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:16168377). Following DNA double-strand breaks, recruited to the sites of damage (PubMed:22120668). Recruited to stalled replication forks via interaction with S
Diseases
- Dementia
- Osteitis Deformans
- Myopathy
- Frontotemporal Dementia
- Aortic Aneurysm, Abdominal
- Vaccinia
- Bone Diseases
- Neurodegenerative Disorders
- Inclusion Body Myositis (disorder)
- Sclerosis
- Neoplasms
- Malignant Neoplasms
- Amyotrophic Lateral Sclerosis
Interacting Proteins
- AMFR
- ASPSCR1
- CHEK2
- Cul1
- CUL4A
- FAF2
- FCHSD2
- GRB2
- NSFL1C
- PPP1CA
Pathways
- Pathogenesis
- Localization
- Complement Activation
- Cell Death
- Membrane Fusion
- Autophagy
- Cell Cycle
- Transport
- Cell Proliferation
- Proteolysis
- Virulence
- Cell Division
- Mitosis
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
- Citrullination
- Dephosphorylation
- Glycosylation
- Acetylation
- Methylation
Research Areas
- Cellular Markers
- DNA Repair
- Membrane Trafficking and Chaperones
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VCP
bosterbio.com/bosterbio-gene-info-cards/VCP
References
PMID: 8413590 by Pleasure I.T., et al. Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein.
PMID: 23349634 by Cloutier P., et al. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.