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Facts about Transitional endoplasmic reticulum ATPase.
Vesicle budding from the tER is an ATP-dependent procedure. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is essential for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
Human | |
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Gene Name: | VCP |
Uniprot: | P55072 |
Entrez: | 7415 |
Belongs to: |
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AAA ATPase family |
15S Mg(2+)-ATPase p97 subunit; IBMPFD; IBMPFDMGC8560; MGC131997; p97; TER ATPase; TERA; transitional endoplasmic reticulum ATPase; valosin containing protein; Valosin-containing proteinMGC148092; VCP; yeast Cdc48p homolog
Mass (kDA):
89.322 kDA
Human | |
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Location: | 9p13.3 |
Sequence: | 9; NC_000009.12 (35056064..35072668, complement) |
Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Cytoplasm, Stress granule. Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787). Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:16168377). Following DNA double-strand breaks, recruited to the sites of damage (PubMed:22120668). Recruited to stalled replication forks via interaction with S
The VCP marker antibody from Boster Bio is a primary antibody that has been validated on Western Blotting, Immunohistochemistry, and ELISA, as well as several other platforms. The antibodies are marketed in a variety of applications, including immunohistochemistry. Find out more about the advantages of using this antibody. We will be discussing the best uses of VCP marker antibody from Boster in this article.
The Boster brand has a long-standing track record of providing high-affinity primary antibodies that are cited in the research community. This is because the company's antibodies are well-validated in Western Blotting, Immunohistochemistry, and ELISA. They are frequently referenced and extensively used by researchers. Researchers cite these antibodies for their high-quality, reproducibility, and affordability.
Other excellent antibodies from Boster include the ANTI-MOUSE/HUMAN MAC-2 (GALECTIN-3) antibody that is widely used in cancer studies. Another popular antibody is the IgA/HA Fab fragment. This antibody targets the protein p62. This protein's Fab fragments are highly purified and highly active and can be used in research and diagnostics.
To ensure high quality and precision, Boster Bio has used different methods to verify their VCP markers. Immunohistochemistry, Western Blotting, and ELISA tests allow for high-sensitivity and specificity. The company's high affinity primary antibodies are extensively utilized in research and are cited and highly reliable.
Boster Bio VCP Markers are used in a variety of research areas and are available in custom and BeNeLux delivery options. Boster Bio VCP markers are made of purified antibodies and are compatible with a broad variety of cell culture medium. Boster Bio products are produced by an ELISA platform which combines exclusive trade secrets with high-sensitivity ELISA kit kits.
Boster Bio has a large library of antibodies and ELISA kit for a variety of applications. The antibodies and ELISA kit are available worldwide to identify biomarkers across a variety of fields, including cancer neuroscience, inflammation, and other diseases. Boster Bio antibody kits can detect a wide range of molecules , and have picogram-level sensitivity. The antibodies are available for human and mouse samples. Boster Bio guarantees each product to work as described.
PMID: 8413590 by Pleasure I.T., et al. Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein.
PMID: 23349634 by Cloutier P., et al. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.