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- Table of Contents
VDAC1 Antibodies
AND VDAC1 ELISA kits, VDAC1 Proteins
Many biological assays use antibodies to detect VDAC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VDAC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VDAC1 antibodies...
Designing a Western blot for VDAC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the VDAC1 Western Blot GuideDesigning an IHC experiment for VDAC1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the VDAC1 IHC GuideVDAC1 Infographic by Boster Bio
All VDAC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01168-1
100 µg/vial
Cat # A01168-1
100 µg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1780
100 μg/vial
Cat # PA1780
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01168
100 μl
Cat # M01168
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M01168-1
20μL, 40μL, 100μL, 200μL
Cat # M01168-1
20μL, 40μL, 100μL, 200μL
VDAC1 Overview
Facts about Voltage-dependent anion-selective channel protein 1.
Voltage-dependent anion-selective channel protein 1 (VDAC1)
Forms a channel through the mitochondrial outer membrane as well as the plasma membrane. The channel in the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; at the plasma membrane it's involved in cell volume regulation and apoptosis.
It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open country has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959).
Gene Information
| Human | |
|---|---|
| Gene Name: | VDAC1 |
| Uniprot: | P21796 |
| Entrez: | 7416 |
Family
| Belongs to: |
|---|
| eukaryotic mitochondrial porin family |
Alternative Names
hVDAC1; MGC111064; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; PORIN; PORIN-31-HL; VDAC; VDAC-1; voltage-dependent anion channel 1; voltage-dependent anion-selective channel protein 1
Molecular Weight
Mass (kDA):
30.773 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.1 |
| Sequence: | 5; NC_000005.10 (133971871..134070987, complement) |
Tissue Specificity
Heart, liver and skeletal muscle.
Subcellular Localizations
Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Alzheimer's Disease
- Neurodegenerative Disorders
- Carcinoma
- Hypoxia
- Edema
- Neuroblastoma
- Posttransfusion Purpura
- Malignant Paraganglionic Neoplasm
- Nervousness
- Malignant Neoplasm Of Lung
- Tumor Progression
Interacting Proteins
- CDK1
- HK1
- ITPR1
- LRRK2
- PRDX6
- RTL10
- SLC25A6
- VDAC2
- VDAC3
- YWHAE
Pathways
- Cell Death
- Transport
- Localization
- Pathogenesis
- Oxidative Phosphorylation
- Cell Growth
- Glycolysis
- Flight
- Mitochondrial Translocation
- Cell Differentiation
- Protein Import
- Cell Proliferation
- Cell Cycle
PTMs
- Phosphorylation
- Cleavage
- Reduction
- Oxidation
Research Areas
- Cellular Markers
- Mitochondrial Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VDAC1
bosterbio.com/bosterbio-gene-info-cards/VDAC1
References
PMID: 8420959 by Blachly-Dyson E., et al. Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel.
PMID: 10501981 by Decker W.K., et al. Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis.
9 Publications of Boster VDAC1 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s43032-021-00779-w, Chronic Hypoxia Inhibits Respiratory Complex IV Activity and Disrupts Mitochondr...
- PubMed ID: 10.1007/s00795-021-00306-5, Nicorandil, an ATP-sensitive potassium channel activation, attenuates myocardial...
- PubMed ID: 10.1002/mnfr.201600576, Lack of β, β‐carotene‐9′, 10′‐oxygenase 2 leads to hepatic mitochond...
- PubMed ID: 10.1002/elps.201700143, Novel chemiluminescent Western blot blocking and antibody incubation solution fo...
- PubMed ID: 30085007, Song H,Telugu BP,Thompson LP.Sexual dimorphism of mitochondrial function in the ...
- PubMed ID: 33129969, Wu L,Guo X,Wong SY,Lu P,Hartson SD,Medeiros DM,Wang W,Clarke SL,Lucas EA,Smith B...
- PubMed ID: 30085007, Sexual dimorphism of mitochondrial function in the hypoxic guinea pig placenta ...
- PubMed ID: 27991717, Lack of %u03B2, %u03B2%u2010carotene%u20109%u2032, 10%u2032%u2010oxygenase 2 lea...
- PubMed ID: 26849429, MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes
*More publications can be found for each product on its corresponding product page