WD repeat domain-containing protein 83 (Wdr83)

Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha through its interaction with EGLN3/PHD3. May promote degradation of HIF1A.

May act by recruiting signaling complexes to a particular upstream activator (By similarity). Also functions as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK answers to specific agonists.