DNA repair protein XRCC1 Antibodies

AND XRCC1 ELISA kits, DNA repair protein XRCC1 Proteins

Many biological assays use antibodies to detect DNA repair protein XRCC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA repair protein XRCC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA repair protein XRCC1 antibodies...

We validate the specificity of these antibodies to DNA repair protein XRCC1 by testing them on tissues known to express XRCC1 positively and negatively. Browse below to find the XRCC1 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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XRCC1 Infographic by Boster Bio

All XRCC1 Products

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Anti-XRCC1 Antibody Picoband®

1 Citations 17 Q&As

Western blot analysis of XRCC1 using anti-XRCC1 antibody (PA1639)

IHC analysis of XRCC1 using anti-XRCC1 antibody (PA1639)

ICC analysis of XRCC1 using anti-XRCC1 antibody (PA1639)

Human, Mouse, Rat

IHC, ICC, WB

$370
Cat # PA1639
100 μg/vial

Anti-XRCC1 Rabbit Monoclonal Antibody

1 Citations 16 Q&As

Western blot analysis of XRCC1 using anti-XRCC1 antibody (M00571)

Immunohistochemical analysis of paraffin-embedded human testis, using XRCC1 Antibody

Immunofluorescent analysis of Hela cells, using XRCC1 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M00571
100 μl

Anti-XRCC1 Antibody Picoband®

16 Q&As

Western blot analysis of XRCC1 using anti-XRCC1 antibody (A00571)

IHC analysis of XRCC1 using anti-XRCC1 antibody (A00571)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB

$370
Cat # A00571
100 μg/vial

XRCC1 Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from Jurkat cells

Human, Mouse, Rat

ELISA

$480
Cat # EKC1604
1 kit, containing one 96-well plate and all necessary reagents

Anti-XRCC1 Mouse Monoclonal Antibody [Clone ID: OTI2D8]

Flow cytometric Analysis of Jurkat cells

HEK293T cells transfected with either XRCC1 (Myc-DDK-tagged) overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-XRCC1 antibody (M00571-1)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-XRCC1 mouse monoclonal antibody

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$523
Cat # M00571-1
100 µl

XRCC1 (NM_006297) Human Over-expression Lysate

Human

$628
Cat # LS007515
20 µg, 100 µg

Anti-XRCC1 Antibody Picoband® (monoclonal, 10E10)

Western blot analysis of XRCC1 using anti-XRCC1 antibody (M00571-2)

IF analysis of XRCC1 using anti-XRCC1 antibody (M00571-2)

Flow Cytometry analysis of Hela cells using anti-XRCC1 antibody (M00571-2)

Human

Flow Cytometry, IF, ICC, WB

$370
Cat # M00571-2
100 μg/vial

XRCC1 Overview

Facts about DNA repair protein XRCC1.

XRCC1 3D structure. Source: alphafold

DNA repair protein XRCC1 (XRCC1)

Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by regulating ADP-ribosyltransferase PARP1 activity.

Gene Information

Human
Gene Name:	XRCC1
Uniprot:	P18887
Entrez:	7515

Family

Belongs to:

No superfamily

Alternative Names

DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster

Molecular Weight

Mass (kDA):
69.477 kDA

Genomic Context


Human

Location:	19q13.31
Sequence:	19; NC_000019.10 (43543311..43575527, complement)

Tissue Specificity

Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).

Subcellular Localizations

Nucleus. Moves from the nucleoli to the global nuclear chromatin upon DNA damage.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Neoplasm Of Lung
Malignant Neoplasm Of Breast
Lung Neoplasms
Mammary Neoplasms
Malignant Squamous Cell Neoplasm
Carcinogenesis
Adenocarcinoma
Colorectal Cancer
Non-small Cell Lung Carcinoma
Colorectal Neoplasms

Xeroderma
Xeroderma Pigmentosum
5,10-methylenetetrahydrofolate Reductase Deficiency
Cytogenetic Abnormality
Leukemia
Stomach Neoplasms
Cholangiocarcinoma

Interacting Proteins

APLF
APTX
CHEK2
MAX
PARP1

PNKP
POLB
Polb
POLI

Pathways

Dna Repair
Cell Cycle
Pathogenesis
Base-excision Repair
Dna Replication
Cell Death
Mismatch Repair
Hypersensitivity
Localization
Methylation
Double-strand Break Repair
Aging
Cell Proliferation

Single Strand Break Repair
Drug Resistance
Metaphase
S Phase
Cell Cycle Checkpoint
Dna Methylation
Cell Growth

PTMs

Phosphorylation
Methylation
Cleavage
Ubiquitination
Oxidation
Ribosylation

Acetylation
Deamination
Sumoylation
Demethylation
Dephosphorylation
Reduction

Deacetylation

Research Areas

Apoptosis
Base Excision Repair
Cancer
DNA Repair
Homologous Recombination

Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XRCC1

References

PMID: 2247054 by Thompson L.H., et al. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

PMID: 11163244 by Whitehouse C.J., et al. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.

1 Publications of Boster DNA repair protein XRCC1 Antibodies & ELISA Kits

PubMed ID: 29156789, Meng Q, Wang S, Tang W, Wu S, Gao N, Zhang C, Cao X, Li X, Zhang Z, Aschner M, J...

*More publications can be found for each product on its corresponding product page