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- Table of Contents
DNA repair protein XRCC1 Antibodies
AND XRCC1 ELISA kits, DNA repair protein XRCC1 Proteins
Many biological assays use antibodies to detect DNA repair protein XRCC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA repair protein XRCC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA repair protein XRCC1 antibodies...
Designing a Western blot for DNA repair protein XRCC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the XRCC1 Western Blot GuideXRCC1 Infographic by Boster Bio
All XRCC1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A00571
100 μg/vial
Cat # A00571
100 μg/vial
Anti-XRCC1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
IHC, ICC, WB
$370
Cat # PA1639
100 μg/vial
Cat # PA1639
100 μg/vial
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M00571-2
100 μg/vial
Cat # M00571-2
100 μg/vial
Anti-XRCC1 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00571
100 μl
Cat # M00571
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1604
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1604
1 kit, containing one 96-well plate and all necessary reagents
XRCC1 Overview
Facts about DNA repair protein XRCC1.
DNA repair protein XRCC1 (XRCC1)
Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by regulating ADP-ribosyltransferase PARP1 activity.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | XRCC1 |
| Uniprot: | P18887 |
| Entrez: | 7515 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster
Molecular Weight
Mass (kDA):
69.477 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.31 |
| Sequence: | 19; NC_000019.10 (43543311..43575527, complement) |
Tissue Specificity
Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
Subcellular Localizations
Nucleus. Moves from the nucleoli to the global nuclear chromatin upon DNA damage.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Breast
- Lung Neoplasms
- Mammary Neoplasms
- Malignant Squamous Cell Neoplasm
- Carcinogenesis
- Adenocarcinoma
- Colorectal Cancer
- Non-small Cell Lung Carcinoma
- Colorectal Neoplasms
Interacting Proteins
- APLF
- APTX
- CHEK2
- MAX
- PARP1
- PNKP
- POLB
- Polb
- POLI
Pathways
- Dna Repair
- Cell Cycle
- Pathogenesis
- Base-excision Repair
- Dna Replication
- Cell Death
- Mismatch Repair
- Hypersensitivity
- Localization
- Methylation
- Double-strand Break Repair
- Aging
- Cell Proliferation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Ubiquitination
- Oxidation
- Ribosylation
Research Areas
- Apoptosis
- Base Excision Repair
- Cancer
- DNA Repair
- Homologous Recombination
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XRCC1
bosterbio.com/bosterbio-gene-info-cards/XRCC1
References
PMID: 2247054 by Thompson L.H., et al. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.
PMID: 11163244 by Whitehouse C.J., et al. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair.
1 Publications of Boster DNA repair protein XRCC1 Antibodies & ELISA Kits
- PubMed ID: 29156789, Meng Q, Wang S, Tang W, Wu S, Gao N, Zhang C, Cao X, Li X, Zhang Z, Aschner M, J...
*More publications can be found for each product on its corresponding product page