This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
DNA repair protein XRCC4 Antibodies
AND XRCC4 ELISA kits, DNA repair protein XRCC4 Proteins
Many biological assays use antibodies to detect DNA repair protein XRCC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA repair protein XRCC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA repair protein XRCC4 antibodies...
Previous: CBLIF
Next: YWHAB
XRCC4 Infographic by Boster Bio
All XRCC4 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1605
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1605
1 kit, containing one 96-well plate and all necessary reagents
Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00787-1
100 μg/vial
Cat # A00787-1
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00787-2
100 μg/vial
Cat # A00787-2
100 μg/vial
XRCC4 Overview
Facts about DNA repair protein XRCC4.
DNA repair protein XRCC4 (XRCC4)
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4).
The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enriches the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of this DNA-dependent protein kinase complex DNA-PK to those DNA ends.
Gene Information
| Human | |
|---|---|
| Gene Name: | XRCC4 |
| Uniprot: | Q13426 |
| Entrez: | 7518 |
Family
| Belongs to: |
|---|
| XRCC4 family |
Alternative Names
complementing defective, repair in Chinese hamster; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4
Molecular Weight
Mass (kDA):
38.287 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q14.2 |
| Sequence: | 5; NC_000005.10 (83077409..83370333) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Genomic Instability
- Chromosomal Translocation
- Carcinogenesis
- Malignant Neoplasm Of Breast
- Immunologic Deficiency Syndromes
- Mammary Neoplasms
- Severe Combined Immunodeficiency
- Lymphoma
- Chromosome Breakage
- Cytogenetic Abnormality
- Ataxia
Interacting Proteins
- APLF
- APTX
- ASTE1
- BIN1
- FAM9B
- LIG4
- NHEJ1
- PNKP
- XRCC6
Pathways
- Dna Repair
- V(d)j Recombination
- Double-strand Break Repair
- Cell Cycle
- Cell Death
- Dna Ligation
- Senescence
- Dna Replication
- Pathogenesis
- Rna Interference
- Transposition
- S Phase
- Localization
PTMs
- Phosphorylation
- Cleavage
- Acetylation
Research Areas
- Cancer
- DNA Double Strand Break Repair
- DNA Repair
- Homologous Recombination
- Non-homologous end-joining
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XRCC4
bosterbio.com/bosterbio-gene-info-cards/XRCC4
References
PMID: 8548796 by Li Z., et al. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.
PMID: 9259561 by Critchlow S.E., et al. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.