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ZBTB4 Antibodies
AND ZBTB4 ELISA kits, ZBTB4 Proteins
Many biological assays use antibodies to detect ZBTB4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZBTB4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZBTB4 antibodies...
Designing an IHC experiment for ZBTB4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ZBTB4 IHC GuideZBTB4 Infographic by Boster Bio
All ZBTB4 Products
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ZBTB4 Overview
Facts about Zinc finger and BTB domain-containing protein 4.
Zinc finger and BTB domain-containing protein 4 (ZBTB4)
Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent method.
Binds with a greater affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and may bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).
Gene Information
| Human | |
|---|---|
| Gene Name: | ZBTB4 |
| Uniprot: | Q9P1Z0 |
| Entrez: | 57659 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
KAISO-L1; zinc finger and BTB domain containing 4
Molecular Weight
Mass (kDA):
105.114 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7459366..7484249, complement) |
Subcellular Localizations
Nucleus. Chromosome. Localizes to chromocenters.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Leukemia
- Metabolic Bone Disorder
- Bladder Neoplasm
- Cell Invasion
- Malignant Neoplasm Of Prostate
- Multiple Malignancy
- Malignant Tumor Of Colon
- Malignant Neoplasm Of Urinary Bladder
Pathways
- Cell Growth
- Methylation
- Dna Methylation
- Gastrulation
- Cell Proliferation
- Regulation Of Gene Expression
- Cell Cycle Arrest
- Dna Ligation
- Drug Resistance
- Cell Cycle
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZBTB4
bosterbio.com/bosterbio-gene-info-cards/ZBTB4
References
PMID: 16354688 by Filion G.J., et al. A family of human zinc finger proteins that bind methylated DNA and repress transcription.
PMID: 19448668 by Yamada D., et al. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.